STUDYTHE EFFECT_ OF THE ANTIHYPERTENSIVE DRUG (TENORMIN) ON SOME BLOOD CHARACTERISTICS AND ON THE ACTIVITY OF ISOLATED LEUKOCYTES MEASURED BY CHEMILUMINESCENCE

Razak N. Khudayer; Abdul

STUDYTHE EFFECT_ OF THE ANTIHYPERTENSIVE DRUG (TENORMIN) ON SOME BLOOD CHARACTERISTICS AND ON THE ACTIVITY OF ISOLATED LEUKOCYTES MEASURED BY CHEMILUMINESCENCE

2006

Razak N. Khudayer | Abdul

tenormin (atenolol) orally daily for more than three years. The other This study had been done on thirty blood samples drown from thirty men between 40-60 years of age half of them suffering from hypertension and taking 100mg ﬁfteen men were healthy and did not taking any drug and regarded as control. Those blood samples were subjected to study some hematological parameters such as hemoglobin percentage and total erythrocyticr and leukocytic counts. Also isolation of leukocytes was done from both hypertensive patient and control and study their activity by chemiluminescence method. v Result showed that prolonged treatment by tenormin of 100 mg orally daily resulted in signiﬁcant decrease (P < 0.0l)in total erythrocytic and leucocytic counts as well as the same signiﬁcant decrease in hemoglobin percentage as compared with controls , it also resulted in significant inhibition of activity of isolated leukocytes as measured by chemiluminescence technique which resulted from their weak reaction with the luminescence material (lucigenin)mixed with it in the measuring chemiluminescence apparatus which is an indication of reduced immunological ability of those leukocytes in addition to their decreased number.

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