SCIATIC NERVE REGENERATION USING AUTOTRANSPLANTATION OF TENDON WITH BONE MARROW IN DOGS
2022
Ahmed Kh. AlJobory
The aim of this study was to evaluate the regenerative activity ofautotransplantation of superficial flexor digital tendon and bone marrowon the repair of sciatic nerve in dogs. Eight adult dogs from both sexeswere used. The age ranges from 1-2 years and weight from 10-15 kgs.The animals were divided into two groups control and treatment groupeach group consists of four animals. Each animal in the first group wasanesthetized with mixture of xylazine and ketamine at a dose of 5 mg/kgand 10 mg/kg of body weight I.M, respectively. The skin of the lateralsurface of the thigh region was incised, fascia and muscle group wereseparated using blunt dissection, the left sciatic nerve was harvested and a10 mm piece was transected. A segment longer than 10 mm of superficialflexor digital tendon was harvested and autografted using 5/0 nylon. Inthe second group animals underwent the same manner of first group aswell as bone marrow applied at operative site. 60 days post operativelyresults exhibited improvement in activity of affected limb in treatedanimals with graft and bone marrow. Histologically there was animprovement at site of graft represented by formation of granulationtissue in both groups. In conclusion the local application of bone marrow on the site of tendon graft led to enhance the regeneration of sciatic nerveresulting in functional improvement of the affected limb
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