SYNTHESIS, CHARECTERIZATION AND ANTIOXIDANT  ACTIVITY OF BIS [4-(4'-HYDROXY-3'-METHOXY  BENZYLIDENE AMINO PHENYL)] TELLURIDE

Hiathem J. Kadhum; Mohammed A. Al-Dewan; Shaker A. S. N. AL-Jadaan

SYNTHESIS, CHARECTERIZATION AND ANTIOXIDANT ACTIVITY OF BIS [4-(4'-HYDROXY-3'-METHOXY BENZYLIDENE AMINO PHENYL)] TELLURIDE

2014

Hiathem J. Kadhum | Mohammed A. Al-Dewan | Shaker A. S. N. AL-Jadaan

Bis[4-(4'-hydroxy-3'-methoxy benzylidene amino phenyl)] telluride (R2Te) was prepared from the reaction of two moles of 4-(4'-hydroxy-5'-methoxybenzylidene amino phenyl) mercuric chloride and one mole of TeBr 4 in dry dioxane to give diorganyl tellurium dibromide (R 2 TeBr2 ) which reduced by boiling ethanolic hydrazine hydrate to give the corresponding new telluride (R 2 Te). R2 Te inhibits nitrite induced methemoglobin formation in hemolysate. The time required to convert 50% of the available hemoglobin to methemoglobin was increased from 2.5 to 4, 5.5 and 10.5 minutes by the addition of (1.25, 5 and 20µM) of test compound (R 2 Te) respectively, and from 7 to 15, 29 and 54 minutes to convert all of the available hemoglobin to methemoglobin. It seems that R 2 Te failed to inhibit nitrite induced hemoglobin oxidation if added after the autocatalytic stage (5-10 minutes after nitrite addition). R 2 Te, a novel organotellurium compound, can inhibit nitrite induced methemoglobin formation in hemolysate in a dose dependent manner if added before the autocatalytic stage.

Показать больше [+]