HISTOPATHOLOGICAL STUDY OF NITRATE ION EFFECT ON PANCREAS EXPERIMENTALLY IN LABORATORY MICE
2016
Salma S.AL- Anni | Zainab R. Zghair | Mohanad D. Al- jaboore | Eman K. Khalel
This study was designed to explore the effect of nitrate ion on induction of diabetesexperimentally in laboratory mice.Fifteen white mice, 7-8 week olds were randomly dividedinto three equal groups. First group was administrated orally o.3 ml of nitrateion(concentration was 0.25gm/10ml D.W) daily for one month. Second group was administratedorally o.3 ml of potassium nitrate (concentration was 0. 5gm/10ml D.W) daily foronemonth. Third group was administrated orally with 0.3 ml of distilled water (D.W) daily forone month.After 30 post administrationthe concentration of blood glucose of infectedanimals treated with nitrate ion increase in both first and second groups when compared withcontrol group.The histopathological change study showed pathological lesions in pancreasof first grouptreated with nitrate ion showed the exocrine region and islets of Langerhans with damageddue to necrosis, while the second group wasinfected with nitrate ion showed the exocrineregion and islets of Langerhans with necrosis and congestion of blood vessel
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