18- STUDY THE EFFECT OF NIZORAL ON SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS IN MALE RABBITS
2018
The present study aimed to determine the potential toxic effects of Nizoral through oral administration on some of blood and biochemical parameters of laboratory rabbits . Eighteen of local normal rabbits were used in the present study . The animal divided randomly to three group ( six animal in each ) .Group one ( control ) the animal treated normal saline .Group two the animals chronically feed by stomach tube Nizoral 20 mg/kg/BW daily for 30 days. Group three the animals chronically feed by stomach tube Nizoral 40 mg/kg/BW daily for 30 days. The investigation included body weight gains (BW) , some blood parameters like red blood cells count (RBC) hemoglobin concentration(Hb), packed cell volume (PCV) and total white blood cell count(WBC) . Biochemical parameters included total serum alan in aminotransferase (ALT), aspartate aminotransferase(AST),and hormones testosterone concentration ,and semen characteristics .The results showed reduced in BW. R.B.C count ,Hb concentrations PCV value were reduced gradually but not reach a significantly . Total W.B.C count lymphocyte and monocyte appeared a significant decrease(p≤0.05) ,but neutrophils showed a significant increase (p≤0.05).The biochemical study refers to a significant increase (p≤0.05) in ALT,AST and a significant decrease(p≤0.05) in hormones testosterone concentration.The testes and epididymis appeared absences of sperms .
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