CARDIOPROTECTIVE AND ANTILIPIDEMIC ROLE OF OCIMUM BASILICUM SEEDS OIL AND LINUM USITATISSIMUM SEEDS OIL IN ACUTE MYOCARDIAL INFARCTION MALE RABBITS INDUCED BY ISOPROTERENOL
2018
Zainab Abbas Hasan | Muna H. AL-Saeed
This study was undertaken to investigate the possible protective effect of Ocimum basilicumseeds oil and Linum usitatissimum seeds oil on heart function, antioxidant and lipid profile test, wheninduced acute myocardial infarction in rabbits by isoproterenol. Thirty-six male rabbits were dividedinto six groups: group (C): control negative, group (ISO): received isoproterenol (control positive),(BP) group: basil seed oil protective group, (FP) group: flaxseed oil protective group, (BT) group:basil seed oil treated group and (FT) group: flaxseed oil treated group. ECG and blood samplestropnine I, antioxidant enzymes and lipid profile were done. The analysis of ECG in rabbits treatedwith isoproterenol showed T wave inversion and an increase in heart rate. While rabbits treated withbasil oil and flaxseed oil restored T wave and heart rate to near normal. The results of the experimentrevealed that administration of basil oil and flaxseed oil in all groups caused a significant decrease(p˂0.05) in cardiac troponin I and lipid profile (TC, TG, LDL, VLDL) and significant increase(p˂0.05) in HDL and antioxidant enzymes Glutathione Peroxidase (GPx) and SuperoxideDismutase (SOD) compare with ISO group. The study concluded the basil oil and flaxseed oil havecardioprotective and ameliorative effects against acute myocardial infarction induced byisoproterenol in experimental animals
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