TOXICO-PATHOLOGICAL STUDY OF GENTAMICIN BY INTRAMUSCULAR INJECTION IN EXPERIMENTAL RABBITS
2018
In the current study, 16 rabbits was divided into two groups. Animals of Group I (untreated control) were maintained without any treatment. Group 2 animals (treated group), the gentamicin were injected in thigh muscle /I.M. at 25 mg/kg body weight twice a day (morning and evening) for two months. During the experimental period anorexia, emaciation, and death some animals were seen. Histopathological examination showed that there was proliferated of cortical renal tubules cells and degeneration with necrosis of some them as well as congestion of sinusoid in liver and proliferation of bile duct. There was also vacuolated and congestion of myocardial tissue. In conclusion, the administration of gentamycin for a long time could serve as a source of harm to animal organs such as kidney, liver, bile duct, and heart
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