HISTOLOGICAL AND PHYSIOLOGICAL STUDY OF DIANABOL ON THE THYROID GLAND OF FEMALE ALBINO RATS (Rattus rattus)
2020
Ekhlas Abid Hamza | Salim Salih Ali | Lubab Aqeel Jafer | Isam Mohamed Jaber
The random uses of androgenic anabolic steroids such as dianabol (Alpha pharma)especially among young people and adolescent could have harmful effects on health.The aim of this study is to investigate the possible harmful effects of oraladministration of dianabol on the histology and hormones levels of the thyroid glandin female rats. The study was carried out in the animal house ( College ofveterinaryMedicine / University of Al-Qasim Green . Twenty four female rats(Rattus rattus ) were divided into 4 groups , three groups were given dianabol orallyat the concentrations of (0.05 , 0.1 , 0.2) mg/kgvrespectively on daily basis for sixweeks , and the fourth group, served as a control group, was injected by (0.9%Nacl).Thyroxine (T4), triiodothyronine(T3) and thyroid stimulating hormone (TSH) wereestimate, Histological study included the histopathological changes in thyroid glandtissue. The results showed a significant increase (p< 0.05) in the levels of TSH, T4,and T3 compared with the control group .This study also showed changes in thethyroid tissue that included hyperplasia of thyroid follicles, colloid material in mostfollicles, little or no increase in the size of follicles which suggest that increased doseof dianabol leads to pathological (Physiological and histological) changes noticeablein most of the studied criteria.
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