THE PROTECTIVE EFFECT OF N-ACETYLCYSTEINE (NAC) AGAINST OXIDATIVE STRESS ENZYME AND LIPID PROFILE FOR TOXICITY MALE RATS BY DIMETHYLNITROSAMINE
2020
Mohammed younis et al.,
The present study is conduct to evaluated the deleterious effects ofadministration of dimethylnitrosamine (DMN) on the some oxidative stress and lipidprofile parameters of laboratory male rats (Rattus rattus), we used eighteen adult malerats randomly divided into three equal groups ( six in each). Group 1 (control) theanimals treated by given oral normal saline (0.2 ml), group 2 was treated by oraldimethylnitrosamine 30 mg/kg/day, group 3 the animals were treated by oral Nacetylcysteine 300 mg/kg/day followed by dimethylnitrosamine 30 mg/kg/day. At theend of experimental period, rats were sacrificed. Blood was collected by cardiacpuncture to investigate lipid profile and oxidative parameters including serum MDA,glutathione, catalase, and SOD. Results showed a significant reduction in SOD,Catalase, glutathione, and HDL, and a significant increase in MDA, LDL, totalcholesterol, triglyceride, after DMN treatment, while these changes were returned tonearly normal level when they combined NAC with DMN treatment for the 30 daystreatment when compared with the control group.
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