The role of diglyceride acyltransferase (DGAT) genes polymorphisms on milk production in dairy goats

Muhammad Safdar; Mehmet Ozaslan

The role of diglyceride acyltransferase (DGAT) genes polymorphisms on milk production in dairy goats

2021

Muhammad Safdar | Mehmet Ozaslan

Milk quantity, fat, and protein contents are important traits in dairy animals, particu-larly in dairy goats. However, little is known about the genetics and genomics in dairy goats that influence these traits. The diacylglycerol O-acyltransferase (DGAT) genes are considered the most important genes in dairy goats for milk quantity and fat con-tents. The DGAT genes have two isoforms as DGAT1 and DGAT2, that have similar re-actions but no sequence homology in-between. The DGAT1 gene in chromosome 14 is a functional and potential candidate gene for fat content in goats, while DGAT2 is associated with milk yield and fat percentage in goats. The phylogenetic analyses re-vealed similar topologies and evolutionary partitioning of DGAT family proteins into two major clades: DGAT1 and DGAT2. Moreover, DGAT1 proteins were found to play a significant role in the milk yield in dairy goats. In this review, the role of polymor-phisms in DGAT family genes on milk production in dairy goats is discussed

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