Key Insights on Therapeutic Potential of Various Phytochemicals against Breast Cancer

Dipika Pal; Pallavi Singh; Madhulika Esther Prasad; Vijay Jagdish Upadhye

Key Insights on Therapeutic Potential of Various Phytochemicals against Breast Cancer

2025

Dipika Pal | Pallavi Singh | Madhulika Esther Prasad | Vijay Jagdish Upadhye

Breast cancer poses a global health challenge and requires innovative approaches for prevention and treatment. Phytochemicals have gained attention for their potential anti-cancer properties by offering promising therapeutic interventions with their many advantageous effects and activity in promoting apoptotic pathways and other molecular pathways involved in breast cancer. Research indicates that phytochemicals have many beneficial effects, including anti-inflammatory, antioxidant, and antiproliferative effects. Phytochemicals have the potential to affect crucial signaling pathways of Breast cancer. Promiscuous phytochemicals such as curcumin, resveratrol, apigenin, and epigallocatechin gallate (EGCG), among others, have demonstrated notable anti-cancer effects in preclinical studies. This review delves deep into the therapeutic action and mechanism of various phytochemicals against breast cancer. It highlights the promiscuous role of multiple phytochemicals, their sources, and their target molecules in breast cancer along with shedding light on some of the limitations of these phytochemicals. It discusses the key role of phytochemicals like Apigenin and Silibinin in combating the progression of Breast cancer and also emerging as crucial avenues to counter chemotherapeutic resistance. Effective treatments and cures should be developed to reduce the burden of non-communicable diseases and ensure human well-being and a good quality of life in order to accomplish sustainable development goals.

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