Study the Therapeutic Role of Zinc and Vitamin D3 in Juvenile Male Rats with Zinc Deficiency; Hormonally and Histologically
2025
Maryam ALmously
The current experience was carried out to evaluated the impacts of Zinc and VitD3 on the thyroid gland, and testicular functions as well as bone tissue architecture in rats with zinc deficiency, forty juvenile rats were used, and Zinc deficiency was induction within a dose of 30 mg/kg of 1,10 phenanthroline dissolved in 0.5 ml of DMSO. Rats were distributed into four groups: group I. Rats served as control without zinc deficiency, was received 1ml of saline, group II with zinc deficiency considered as positive control, was received 1ml of saline, group III with deficiency, was treated with zinc 20mg /kg , group IV with Zn deficient, was treated with Vit D3 at a dose of 500 IU/kg, all groups treated orally for 30 days consecutive, our findings indicating that zinc deficiency caused to elevated TSH and T4 while lowered T3 values, markedly decreased in testosterone, FSH and LH, whereas histopathological alteration in bone its representing by loss of trabecular mass and atrophy of the osteoblast were observable, while the administration of zinc and Vit D led to improvement thyroid and sexual hormones as well osteoblast activity. In Conclusion zinc deficiency causing harmful impacts on thyroid gland, spermatogenesis and bone mineralization, while the administration of zinc and Vitamin D results in improvement hormone levels and restoration of the histopathological changes in the bone.
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