Dithiocarbamate mancozeb, an organometallic fungicide, was administered orally to male Wistar rats in two forms, pure technical 85% and formulated 80% WP, at sublethal doses of 125, 250 and 500 mg/kg b.w. for 28 days. Clinical chemical endpoints were measured after 2, 3, and 4 weeks of treatment initiation.  Data disclosed that both compound formulations affected significantly serum enzyme activities particularly liver enzymes in a dose and time-dependent manner, compared with control. Such changes were accompanied with significant alterations in other parameters like; total protein, albumin, glucose, total lipids, triglycerides, cholestrol, urea, and creatinine.  Furthermore, histological examination of liver and kidney showed several histopathogenic ubnormalities in the examined tissues of rats exposed to mancozeb either technical or formulated.

Laboratory and field trials were carried out at Koom Hamada district and Etay El-baroud research station during 2004/ 2005 season to clarify the molluscicidal ac-tivities of the following: indoxacarb, lufenuron, Bacillus thurringiensis, kurestaci (Bt.) and methomyl against glassy clover snails Monacha cartusiana (Müler). Re-sults indicated that all tested pesticides decreased snails population compared with control. Under the field conditions, the efficiency of the tested compounds were 98.0, 93.4, 93 and 71.58% for methomyl, lufenuron, indoxacarb and Bt. after 5, 6, 13, and 28 days of treatment, respectively. Moreover the effect of LC50 and 0.5 LC50 of these compounds were investigated on some biochemical parameters in vivo. The activities of acetylcholinestrase (AChE), alanine aminotransferases (ALT) , as-partate aminotransferases (AST) and protein contents at different time intervals were evaluated. The specific activity of AChE reached 0.009, 0.002, 0.006 and 0.001 mole/ mg protein/ min for indoxacarb, lufenuron, Bt. and methomyl, respectively, after one day of treatment with (LC50 for each compound). In general, Bt. and in-doxacarb caused slight inhibition on AChE enzyme. All treatments decreased ALT and AST enzyme activity in the tested animals. However, Bt. Showed slight effect on the activity of aminotransferases enzymes.