Improving the nutritional status of plants is an effective method for enhancing their ability to withstand drought stress. To evaluate the quantitative, qualitative, and antioxidant properties of castor plant under water deficit conditions stress and foliar application of chemical fertilizers, an experiment was conducted as a split-plot design in a completely randomized block design with three replications. The first factor was irrigation levels including control (normal irrigation), irrigation after 80 mm and 140 mm evaporation from the pan evaporation in the main plots, and eight spraying chemical fertilizers (sulfur, potassium, nitrogen, sulfur+potassium, sulfur+nitrogen, potassium+nitrogen, sulfur+potassium+ nitrogen and control (no spraying)) were included in subplots. The highest proline content, catalase, peroxidase, superoxide dismutase, and total phenol were obtained under irrigation after 140 mm of evaporation conditions and foliar application of nitrogen+potassium+sulfur. Also, the highest grain yield, oil yield, and the lowest oil percentage were observed in the nitrogen+potassium foliar treatment under irrigation conditions after 20 mm of evaporation. Although the content of malondialdehyde increased in water deficit stress treatments, nitrogen+potassium+sulfur and nitrogen+potassium foliar application significantly reduced the peroxidation of membrane lipids (malondialdehyde) under irrigation conditions after 80 and 140 mm of evaporation compared to the control treatment. In conclusion, foliar application of chemical fertilizers in castor can improve the resistance to water stress by strengthening the antioxidant system and then increase its grain and oil yield.