Atherosclerosis is one of the risk factors for coronary artery disease. The present study was conducted to find out the alleviative effect of ethanolic extract of Mirabilis jalapa L. against haemato-biochemical alterations of high-fat diet-induced atherosclerosis in Wistar rats. Fifty-four Wistar rats (male – 27 and female – 27) were randomly divided into six different groups: Group I (normal pellet feed), group II (high-fat diet), group III (root extract of Mirabilis jalapa L.), group IV (atorvastatin), group V (HFD + root extract of Mirabilis jalapa L.) and group VI (HFD + atorvastatin). The treatments were given from the 8thday to the 30th day in group V and group VI. Haematological parameters, hepatic enzymes, serum lipid profile and atherogenic indices were studied in HFD induced atherosclerosis. Ethanolic extract of M. jalapa L. (EEM) showed a highly significant reduction in lipid profile, atherogenic indices, hepatic enzymes (ALT and AST) compared with the HFD group. No significant differences were observed in the haematological values of all the groups. The results indicated that M. jalapa L. has a partial alleviative effect on HFD induced biochemical changes in the atherosclerotic rat.

In this study, the experiment was designed to investigate the effect of daily oral administration of (0.5gm/kg. B.W) of chicory (Chicorium intybus) for one month on weight and histology of kidney and liver of hypercholesterolemic rabbits (induced by oral administration of 0.5 gm/kg of cholesterol dissolved in 3ml Soya bean oil) and compared this effect with medicial therapy used for atherosclerosis treatment . The results revealed a significant increase (P

The chemotactic activity of turkey peritoneal macrophages in response to an atherosclerotic plaque extract from a hypertensive strain of turkeys was determined. Atherosclerotic plaque extract stimulated macrophage chemotaxis, whereas normal aortic extract did not stimulate macrophage chemotaxis. However, differences were not revealed by sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of extracts of atherosclerotic plaque and normal aorta. Chemotactic activity was diminished with pronase treatment, suggesting the chemoattractant is a protein. Seemingly, atherosclerotic plaque of turkeys contains a macrophage chemotaxin.