The experiment was applied on /45/ healthy male of golden Syrian hamsters, were divided into three groups as follows: Control group(C), High Fat-High Cholesterol group(HF-HC) and Borage Oil group (BO). All groups had laboratorial diet freely during/15/ days(first period), after that each of HF-HC and BO groups took diet consisting of 80% laboratorial diet+ 20% fats(13.5% sheep fat+6.5% coconut oil) for /4/ weeks(second period). The treatment of BO group changed after second period and hamsters had laboratorial diet and dosed borage oil 2g/kg of the body weight daily for /4/ weeks(third period). The results showed a significant increase(p=0.0000) of the total cholesterol(TC), low density lipoprotein cholesterol (LDL-C) and triglycerides(TG) concentrations approximately(163%, 224%, 232%) respectively in each of HF-HC and BO groups in the second period in comparison with first period. Our results showed, in third period, a dramatic significant decrease(P=0.0000) in the TC, LDL-C and TG concentrations approximately (56%, 69%, 40%) respectively in BO group in comparison with the same group of second period