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Efficacy of ivermectin against Dirofilaria immitis larvae in dogs 30 and 45 days after induced infection.
1986
Paul A.J. | Todd K.S. Jr. | Sundberg J.P. | DiPietro J.A. | McCall J.W.
Lymphangiographic evaluation of experimentally induced chylothorax after ligation of the cranial vena cava in dogs.
1986
Fossum T.W. | Birchard S.J.
Correlative biomechanical and histologic study of the cranial cruciate ligament in dogs.
1985
Vasseur P.B. | Pool R.R. | Arnoczky S.P. | Lau R.E.
Single-injection method for evaluation of nenal function with C-inulin and H-tetraethylammonium bromide in dogs and cat.
1985
Fettman M.J. | Allen T.A. | Wilke W. | Radin M.J. | Eubank M.C.
Efficacy of imidacloprid for removal and control of fleas (Ctenocephalides felis) on dogs.
1997
Arther R.G. | Cunningham J. | Dorn H. | Everett R. | Herr L.G. | Hopkins T.
Effect of volume variations on osteogenic capabilities of autogenous cancellous bone graft in dogs.
1996
DeVries W.J. | Runyon C.L. | Martinez S.A. | Ireland W.P.
Pharmacokinetics, effects on renal function, and potentiation of atracurium-induced neuromuscular blockade after administration of a high dose of gentamicin in isoflurane-anesthetized dogs.
1996
Martinez E.A. | Mealey K.L. | Wooldridge A.A. | Mercer D.E. | Cooper J. | Slater M.R. | Hartsfield S.M.
Pharmacokinetic model for cefazolin distribution during total hip arthroplasty in dogs.
1996
Marcellin Little D.J. | Papich M.G. | Richardson D.C. | DeYoung D.J.
Influence of allopurinol and two diets on 24-hour urinary excretions of uric acid, xanthine, and ammonia by healthy dogs.
1995
Bartges J.W. | Osborne C.A. | Felice L.J. | Unger L.K. | Chen M.
Hyperxanthinuria and xanthine uroliths have been recognized with increased frequency in dogs with ammonium urate uroliths that had been given allopurinol. We hypothesized that dietary modification might reduce the magnitude of uric acid and xanthine excretion in urine of dogs given allopurinol. To test this hypothesis, excretion of metabolites, volume, and pH were determined in 24-hour urine samples produced by 6 healthy Beagles during periods of allopurinol administration (15 mg/kg of body weight, PO, q 12 h) and consumption of 2 special purpose diets: a 10.4% protein (dry matter), casein-based diet and a 31.4% protein (dry matter), meat-based diet. Significantly lower values of uric acid (P = 0.004), xanthine (P = 0.003), ammonia (P = 0.0002), net acid (P = 0.0001), titratable acid (P 0.0002), and creatinine (P = 0.01) excreted during a 24-hour period were detected when dogs consumed the casein-based diet and were given allopurinol, compared with the 24-hour period when the same dogs consumed the meat-based diet and were given allopurinol. For the same 24-hour period, urine pH values, urine volumes, and urine bicarbonate values were significantly (P = 0.0004, P 0.04, and P = 0.002, respectively) higher during the period when the dogs were fed the casein-based diet and given allopurinol than when they were fed the meat-based diet and given allopurinol. Endogenous creatinine clearance was significantly (P = 0.006) lower when dogs were fed the casein-based diet and given allopurinol than when they were fed the meat-based diet and given allopurinol. Significantly lower concentrations of plasma uric acid (P 0.0001), plasma xanthine (P = 0.01), and serum urea nitrogen (P = 0.0001) were detected when dogs consumed the casein-based diet and were given allopurinol than when they consumed the meat-based diet and were given allopurinol.
Показать больше [+] Меньше [-]Comparison of estrogen and progesterone receptor expression in normal and tumor mammary tissues from dogs.
1995
Donnay I. | Rauis J. | Devleeschouwer N. | Wouters Ballman P. | Leclercq G. | Verstegen J.
Concentrations of estrogen (ER) and progesterone (PR) receptors were measured by radioreceptor assay in tumor (n = 319) and normal (n = 166) mammary tissue from 248 bitches. Correlations between ER and PR and between receptor expression in tumor and normal mammary tissue from the same bitches were evaluated. The influence of tumor, clinical, or hormonal variables on receptor expression also was studied. Approximately 80% of tumor and 95% of normal mammary tissue expressed detectable concentrations of ER, PR, or both. Direct correlation was found between ER and PR concentrations in normal and tumor tissues. Median ER concentrations were significantly higher (46 +/- 47 fmol/mg of cytosolic protein vs 27 +/- 24 fmol/mg of cytosolic protein; P = 0.0002) in normal than in tumor tissue. On the other hand, PR concentrations were significantly higher (57 +/- 52 fmol/mg vs 77 +/- 99 fmol/mg; P = 0.03) in tumors (especially benign tumors) than in normal tissue. Poorly differentiated malignant tumors expressed lower concentrations of receptors than did benign or well differentiated malignant tumors. The ER and PR concentrations decreased with increasing size of the lesion. Hormonal status of the bitch significantly (P < 0.05) influenced receptor expression in normal tissue: bitches in the luteal phase of the estrous cycle had higher concentrations of ER (69 +/- 62 fmol/mg) than did ovariectomized bitches (24 +/- 19 fmol/mg) or bitches in anestrus (38 +/- 45 fmol/ mg) or the follicular phase (13 +/- 7 fmol/mg). For PR, higher concentrations were observed in normal tissue during anestrus than during pseudopregnancy or in bitches treated with medroxyprogesterone acetate. Similar, but nonsignificant, variations were seen in tumor tissue except in medroxyprogesterone acetate-treated bitches in which PR concentrations were high in tumors and low in normal tissue from the same bitches.
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