Уточнить поиск
Результаты 1-4 из 4
Clinical efficacy and toxicity of doxorubicin encapsulated in glutaraldehyde-treated erythrocytes administered to dogs with lymphosarcoma.
1994
Matherne C.M. | Satterfield W.C. | Gasparini A. | Tonetti M. | Astroff A.B. | Schmidt R.D. | Rowe L.D. | DeLoach J.R.
Doxorubicin was encapsulated in canine erythrocytes, treated with 0.32% glutaraldehyde, and administered at a dosage equivalent to 30 mg of free doxorubicin/m(2) of body surface area to dogs with diagnosis of lymphosarcoma. Compared with administration of free doxorubicin, this method of drug delivery substantially reduced peak plasma concentration and prolonged higher plasma concentration of doxorubicin. As such, this method was comparable to continuous IV infusion. Previous studies have indicated this method's potential for reduction in toxic side effects, particularly cardiotoxicosis, while allowing higher total doses of doxorubicin to be administered. In this study, doxorubicin encapsulated in glutaraldehyde-treated erythrocytes induced a triphasic exponential decay of doxorubicin from plasma, the highest relative contribution to the total area of the curve being the terminal phase. The treatment was effective in inducing complete and partial remissions of lymphosarcoma, with minimal acute toxicosis and no evidence of cardiotoxicosis. However, substantial, unanticipated, chronic, nonregenerative myelosuppression developed, and was most strikingly expressed as profound thrombocytopenia. Efforts to ameliorate or circumvent this toxic effect will be required prior to further consideration of this doxorubicin delivery system for treatment of systemic neoplasia.
Показать больше [+] Меньше [-]Effects of garlic on the cadmium accumulation in the tissue on the hematological picture in dogs.
1994
Lee B.J. | Sung E.J. | Lee M.S. | Jang I.H. | Lee H.B.
Clinicopathological observations on the experimental pancreatitis induced by ligation of pancreatic ducts
1994
Sung, E.J. | Lee, H.B. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine)
Studies on the artificial infection and the hematological change with Fasciola hepatica metacercariae in rats
1994
Kang, S.W. (Rural Development Administration, Anyang (Korea Republic). Veterinary Research Institute)
