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Coxofemoral joint laxity from distraction radiography and its contemporaneous and prospective correlation with laxity, subjective score, and evidence of degenerative joint disease from conventional hip-extended radiography in dogs
1993
Smith, G.K. | Gregor, T.P. | Rhodes, W.H. | Biery, D.N.
A 3-year prospective study of large-breed dogs (4 months to 3 years of age) was conducted to evaluate the influence of radiographic positioning and age on coxofemoral joint (hip) laxity, subjective hip score, and development of degenerative joint disease (DJD). The dogs (n = 142) were breeder- or client-owned and represented 14 breeds. With dogs under heavy sedation, hips were radiographed in the standard hip-extended position and in the new compression/distraction position at 4, 6, 12, 24, and 36 months of age. The standard hip-extended radiographic view was evaluated by 3 methods: subjective evaluation by a board-certified veterinary radiologist (WHR), according to the standard 7-point Orthopedic Foundation for Animals (OFA) scoring scheme (OFA/WHR); joint laxity quantitation, using the Norberg angle (NA) method; and subjective scoring by a veterinary orthopedic surgeon for radiographic evidence of DJD. The hips in the distraction radiographic view were evaluated for passive hip laxity, as measured by use of a unitless distraction index (DI). Results of the study indicated that at a specific age (4, 6, 12, 24, or 36 months), all methods of hip evaluation correlated with each other at a moderate level (P < 0.05). The strength of contemporaneous correlation tended to increase with age of evaluation. Longitudinally, the between-method correlations were usually significant (P < 0.05), but not at a sufficiently high level to permit reliable between-method prediction. Prospective intraclass (within-method) statistical analysis of the various hip-scoring methods indicated that DI was superior to NA and OFA/WHR in comparability of score over time. The intraclass correlation coefficient ranged from 0.55 to 0.91 for DI in contrast to 0.40 to 0.78 for NA, and 0.06 to 0.39 for OFA/WHR over the age intervals of the study. For reference, the highest Kappa of 0.39 for the subjective OFA/WHR scoring reflected a maximal level of agreement between time intervals, only slightly better than chance. The associated large error questions the predictive use of the 7-point, subjective hip-scoring scheme, particularly prior to the age of 2 years.
Показать больше [+] Меньше [-]Effect of homologous fibrin adhesive on callus formation and extracortical bone bridging around a porous-coated segmental endoprosthesis in dogs
1993
Roy, R.G. | Markel, M.D. | Lipowitz, A.J. | Gottsauner-Wolf, F. | Taswell, H.F. | Chao, E.Y.S.
Modular, porous-coated, titanium segmental endoprostheses were implanted bilaterally in the femoral diaphysis of 7 adult mixed-breed dogs. Autogenous bone graft in particle form was placed around the implant and bone. In 1 limb, homologous fibrin adhesive was mixed with the graft in situ before soft tissue closure. The contralateral limb was grafted in identical manner, but without fibrin adhesive, and served as a control. Radiography was performed immediately after surgery and 1, 2, 3, 4, 6, 8, 10, and 12 weeks later to assess callus area and bone remodeling. At 12 weeks, dogs were euthanatized and bone/ implant fixation strength was tested under torsion and compared with values for 6 in vitro controls. Histomorphometric and microradiographic analyses of transverse sections of the distal portion of the implanted femurs were performed. Radiographic callus area was significantly (P < 0.05) smaller in the femurs grafted with fibrin adhesive, compared with the contralateral control. New bone formation (21.4 +/- 1.8% vs 19.2 +/- 2.4%), unlabeled bone (64.8 +/- 3.0% vs 67.9 +/- 4.2%), porosity (13.9 +/- 0.7% vs 12.9 +/- .8%), and bone ingrowth into the porous coating (10.3 +/- 0.9% vs 10.0 +/- 1.2%) were not significantly different between fibrin- and nonfibrin-grafted implants, respectively. There were no significant differences in torsional strength of implant fixation between the fibrin- and nonfibrin-grafted femurs or between the in vivo implanted femurs and the in vitro controls. These data indicate that fibrin adhesive may have been advantageous in maintaining apposition of bone graft adjacent to the endoprosthesis, but it probably did not have an enhancing effect on extracortical bone bridging or ingrowth over a porous-coated segmental bone replacement endoprosthesis.
Показать больше [+] Меньше [-]Effects of dietary electrolyte balance on subluxation of the femoral head in growing dogs
1993
Kealy, R.D. | Lawler, D.F. | Monti, K.L. | Biery, D. | Helms, R.W. | Lust, G. | Olsson, S.E. | Smith, G.K.
Effects of increased dietary chloride and reduced sodium and potassium ion concentrations on coxofemoral joint conformation, as assessed by radiography, were examined in growing dogs. Dietary electrolyte balance was quantified by dietary anion gap (DAG), defined as Na+ + K+ - Cl- in milliequivalents per 100 g of food. Diets had anion gap ranging from 8 to 41 mEq/100 g of food. One hundred sixty-seven pups from 27 litters representing 5 breeds were studied during the period of rapid growth. The extent of subluxation of the femoral head was measured on radiographs, using the method of Norberg. On average, less subluxation of the femoral head (P < 0.05) was observed when diets with lower DAG were fed. Differences in DAG balance did not result in different rates of weight gain; therefore, the reduction in coxofemoral joint subluxation attributable to low DAG was unrelated to weight gain. Norberg angles measured at 30 weeks of age were highly correlated with coxofemoral joint status at 2 years of age, as measured by the Swedish diagnostic system and the scoring system of the Orthopedic Foundation for Animals (/r/ greater than or equal to 0.70, P < 0.0002, n = 24). This diet-related improvement in coxofemoral joint sub-luxation would be expected, on average, to delay or mitigate the characteristic clinical and radiographic signs of hip dysplasia in growing dogs.
Показать больше [+] Меньше [-]Biomechanical study of the effect of coxofemoral positioning on passive hip joint laxity in dogs
1993
Heyman, S.J. | Smith, G.K. | Cofone, M.A.
Ten coxofemoral joints from 5 dog cadavers were used to study the effect of coxofemoral positioning on passive hip laxity. A material test system was used to measure lateral translation when force was between 20 N of compression and 40 N of distraction. Using the orthogonal coordinate system imposed in this study, neutral position was empirically defined at 15 degrees of extension and 10 degrees of abduction, relative to the plane of the pelvis, and no internal or external rotation of the femur. The hips were mounted in a custom-designed jig that allowed 1 rotational degree of freedom (ie, either flexion/extension, adduction/abduction, or internal/external rotation), while holding the other 2 constant. Lateral translation of the hips was tested at 10 degrees intervals from 30 degrees of flexion to 70 degrees extension, 40 degrees of adduction to 60 degrees of abduction, and 30 degrees of internal rotation to 40 degrees of external rotation. Lateral displacement was maximal at 10 degrees of extension, 20 degrees of abduction, and 10 degrees of external rotation, approximating the neutral coxofemoral position during stance. As the hips were rotated into extreme positions, the amount of lateral displacement occurring with the same applied load decreased significantly to 32.0 to 65.3% of the maximal displacement. Determining the position of the hip associated with maximal passive laxity in vitro is essential to the design of a precise and accurate clinical stress-radiographic method to quantitate joint laxity in dogs. Our results confirm earlier work that passive hip joint laxity is at a maximum with the hip approximately in a neutral weight-bearing position.
Показать больше [+] Меньше [-]Radiographic study of homotypic variation of long bones in dogs
1993
Markel, M.D. | Sielman, E.
Dogs have been used extensively as an experimental model for studying musculoskeletal disorders. Many of these studies incorporated sequential radiography to quantitate a particular treatment's effect, using the contralateral bone as the control condition. The contralateral bone can be used as a control only if there is bilateral symmetry between right and left limbs. We performed radiography (craniocaudal and lateromedial views) on 10 pairs of humeri, radii, femora, and tibiae from dogs, using an alignment jig, to radiographically determine homotypic geometric variations of long bones. The bones were divided into 5 regions: proximal epiphysis, proximal metaphysis, diaphysis, distal metaphysis, and distal epiphysis. The total bone diameter, medullary diameter, and cortical width (total of medial + lateral cortex or total of cranial + caudal cortex) were measured at specified slices throughout each of these regions. Fourteen of 540 homotypic comparisons revealed significant differences between right and left bones at either a slice or region. Although there were only 14 significant differences between right and left bones at any region or slice, measurements were more precise with lower coefficients of variation in the diaphyseal and epiphyseal regions. Homotypic differences in diaphyseal and epiphyseal regions were < 5.3 and 7.5%, respectively power = 0.8). In metaphyseal regions, however, homotypic differences were larger; these differences could have been as large as 11.5% for total bone diameter, 15.6% for medullary diameter, and 80.0% for cortical width without achieving significant differences between populations (power = 0.8). This study validated the concept of using the contralateral limb as the control condition in orthopedic studies using dogs, particularly when evaluating the geometric properties of long bones radiographically.
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