Production examination of efficiency of concentrated vaccine against swine erysipelas from matrix Konev of trial series, control of its immunizing power and production experiments of biological preparation were realized in the conditions of the Republic of Belarus. Research results showed that the presented vaccine had more expressed immunogenic properties in comparison with its production analogue and provided piglets protection against infection. There was analyzed the immunological efficiency of the vaccine: determination of quantity of erythrocytes; leukocytes; content of hemoglobin, level of lysozyme activity, bacterial growth-inhibitory activity, blood serum, phagocytic activity, neutrophilic leukocytes, content of total protein and protein fractions, titre of erysipelas antibodies, and preventive properties of blood serum. Efficiency of biological preparation was determined on the basis of analysis of disease incidence rate, loss of immunized swine caused by swine erysipelas

Evaluation of pathogenicity of Paenibacillus alvei culture obtained from a dead bee brood from Berezinsky Biosphere Nature Reserve was realized in the conditions of the Republic of Belarus by an example of 30-day old white male mice with body weight of 16-18 grams. Experimental animals were infected with European foul brood (Paenibacillus alvei) intraperitoneally. Research results showed that bacteria Paenibacillus alvei after the intraperitoneal infection with various amount of microbial cells did not cause mouse death; i.e. it was not pathogenic for white mice. In course of the realized observations over the laboratory mice after introduction of infection there were stated no changes in mice behavior and overall condition. There were no visible pathologicoanatomic changes in internal organs. After the bacteriologic examination of internal organs and blood there were isolated pure cultures of Paenibacillus alvei

In the conditions of the Republic of Belarus by an example model of a purulent wound at rats there was realized an experimental study of pharmacological activity of a medical remedy PhytoMP (containing active substances of Macleaya microcarpa (Maxim.) Fedde of Papaveraceae family; and Plantago major L. of Plantaginaceae family) in the form of powder. It was established, that the intensity wound-healthing effect depended on a ratio of the components plume poppy / greater plantain 1 + 1:1, 2:1, 1:2. Studying of the remedy safety showed that PhytoMP in the maximal dozes was not toxic for animals after a single unitary intragastric administration in dose of 50000 mg/kg to mice and in dose of 20833 mg/kg to rats. The mentioned above indexes surpassed the recommended for human dose after application tonsilles (1,428 mg/kg) in 35014 and 14589 times, and also the recommended for human doses for application at a wound with size of 2x2 square cm (11,424 mg/kg) - in 4377 and 1824 times, respectively.