This study was carried out to determine the prognostic importance of troponin enzyme levels in lambs with White Muscle Disease (WMD). Materials and Methods: This study consisted of 50 male and female lambs aged 0-3 months old, 30 of which had clinical white muscle disease (Group I) and 20 of which were healthy (Group II – Control Group). Group I was composed of lambs that showed clinical symptoms of the disease. The disease was also identified by laboratory analysis. The lambs in this group were treated and the course of the disease was followed for 15 days.Compared with the control group, the Group I before treatment results were as follows: AST, LDH, CK, CK-MB, Troponin I and T (P<0.001) were high, while GSH-Px (P<0.001), SOD (P<0.01), Se (P<0.01), Retinol and Tocopherol were low. Compared with the control group, the Group I After Treatment results were as follows: AST, CK, Troponin T (P<0.001) were high, LDH (P<0.01) was high and GSH-Px (P<0.01) was low. Comparing Group I Before Treatment and After Treatment results, AST, CK, CK-MB and Troponin I (P<0.001), as well as GSH-Px, SOD and Se (P<0.01) were high. It was determined that LDH decreased and Tocopherol increased. Whereas Vitamin D3 was determined to be insignificant in all three groups, the levels of CK-MB, Troponin I, Retinol, SOD and Se were insignificant in the After Treatment and control groups, and the Troponin T and retinol values were measured to be insignificant in the Before Treatment and After Treatment groups.To conclude, measuring the AST, CK, CK-MB, LDH values as well as Troponin can be an important parameter for the identification and prognosis of WMD.