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Systemic and pulmonary antibody response of calves to Pasteurella haemolytica after intrapulmonary inoculation.
1992
McBride J.W. | Corstvet R.E. | Paulsen D.B. | McClure J.R. | Enright F.M.
Systemic and pulmonary antibody responses of calves to Pasteurella haemolytica were evaluated by measuring immunoglobulin production in blood for 9 days and in pulmonary lavage fluid for 7 days after intrapulmonary inoculation. Clinical signs, pulmonary lesions, pulmonary and systemic inflammatory response, and amount of antigen in lavage fluid were used to evaluate the response of calves to challenge with P haemolytica. The pulmonary response consisted of production of IgG, IgE, and IgM antibodies to P haemolytica antigens and a 17- to 68-fold increase of cells in lavage fluid 8 hours after inoculation, with a gradual decrease toward normal. Antibodies of the IgM isotype to P haemolytica were demonstrated as early as 8 hours through 7 days after inoculation in 3 of 3 calves. Of the anti-P haemolytica isotypes, IgM was found in the highest concentration. In all of the inoculated calves, IgE was found 1 to 2 days after inoculation, and IgG was found in 2 of 3 inoculated calves from day 1 through 7 after inoculation. Detection of IgG correlated with smaller pulmonary lesions. Immunoglobulin A was not detected in lavage fluid. Serum was evaluated for IgG and IgM antibody response to P haemolytica. Specific IgM was detectable 5 days after inoculation, and IgG was detectable 7 days after inoculation. Pasteurella haemolytica antigens were not detected in serum or plasma. A transient increase in neutrophil count was found 8 hours after inoculation, with return to baseline values by 24 hours after inoculation. Antigen was detected in lavage fluid by use of monoclonal antibodies against selected P haemolytica capsular antigen, outer membrane antigens, and leukotoxin in all inoculated calves 8 hours after inoculation. The monoclonal antibody specific for P haemolytica capsule provided the best detection of antigen. The other monoclonal antibodies detected antigen, but were less consistent.
Показать больше [+] Меньше [-]Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (1) - Effect of serum AST, ALT, LDH activities, lipid content and liver peroxide content.
1992
Kim K.S. | Park J.H.
Cerebral lesions of encephalitozoonosis in rabbits died of rabbit hemorrhagic disease
1992
Park, J.H. | Itakura, C. (Hokkaido Univ., Sapporo (Korea Republic). Dept. of Veterinary Medicine) | Lee, Y.S. (Seoul Nat'l Univ., Suwon (Korea Republic). Dept. of Veterinary Medicine)
Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats - (2) - Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content
1992
Kim, K.S. (Kyungpook National University, Taegu (Korea Republic). Department of Veterinary Medicine) | Park, J.H. (Choong Ang Chemical Company, Seoul (Korea Republic))
