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Long-circulating and target-specific distributions of cyanine 5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days after a single administration
2018
Yun, T.S., Chungbuk National University, Cheongju, Republic of Korea | Chunmei Lin, Jilin Agricultural University, Changchun, Republic of Korea | Yon, J.M., Chungbuk National University, Cheongju, Republic of Korea | Park, S.G., Chungbuk National University, Cheongju, Republic of Korea | Gwon, L.W., Chungbuk National University, Cheongju, Republic of Korea | Lee, J.G., Chungbuk National University, Cheongju, Republic of Korea | Baek, I.J., University of Ulsan College of Medicine, Seoul, Republic of Korea | Nahm, S.S., Konkuk University, Seoul, Republic of Korea | Lee, B.J., Chungbuk National University, Cheongju, Republic of Korea | Yun, Y.W., Chungbuk National University, Cheongju, Republic of Korea | Nam, S.Y., Chungbuk National University, Cheongju, Republic of Korea
Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320-400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet fully understood. After a dose of 5 mg/kg of cyanine 5.5-labeled HA-NPs or HA-polymers was intravenously administrated into mice, the fluorescence was measured from 0.5 h to 28 days. The HA-NPs fluorescence was generally stronger than that of HA-polymers, which was maintained at a high level over 7 days in vivo, after which it gradually decreased. Upon ex vivo imaging, liver, spleen, kidney, lung, testis and sublingual gland fluorescences were much higher than that of other organs. The fluorescence of HA-NPs in the liver, spleen and kidney was highest at 30 min, where it was generally maintained until 4 h, while it drastically decreased at 1 day. However, the fluorescence in the liver and spleen increased sharply at 7 days relative to 3 days, then decreased drastically at 14 days. Conversely, the fluorescence of HA-polymers in the lymph node was higher than that of HA-NPs. The results presented herein may have important clinical implications regarding the safety of as self-assembled HA-NPs, which can be widely used in biomedical applications.
Показать больше [+] Меньше [-]Chemopreventive effects of garlic and mugwort mixture extract on Helicobacter pylori-associated mouse gastric carcinogenesis
2014
Youm, S.Y., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.W., Chungbuk National University, Cheongju, Republic of Korea | Shin, S.K., Chungbuk National University, Cheongju, Republic of Korea | Jeong, H.S., Chungbuk National University, Cheongju, Republic of Korea | Kang, J.K., Chungbuk National University, Cheongju, Republic of Korea | Kim, T.M., Chungbuk National University, Cheongju, Republic of Korea | Kim, K.H., Cosan Institute of Water Science, Seoul, Republic of Korea | Ahn, B.W., Chungbuk National University, Cheongju, Republic of Korea
Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ¥�-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.
Показать больше [+] Меньше [-]Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
2014
Yu, E.A., Tongyeong National Quarantine Station, Ministry of Health & Welfare, Tongyeong, Republic of Korea | Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Park, E.K., (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University, Busan, Republic of Korea | Yoo, C.Y., Department of Computer Information, Gyeongnam Provincial Namhae College, Namhae, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20§¡/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4 ¡¿MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
Показать больше [+] Меньше [-]Dietary zinc inhibits the formation of colonic preneoplastic lesion induced by azoxymethane and dextran sodium sulfate in mice
2012
Park, H.J., Chungbuk National University, Cheongju, Republic of Korea | Kim, D.Y., Chungbuk National University, Cheongju, Republic of Korea | Kang, B.S., Chungbuk National University, Cheongju, Republic of Korea | Yoon, J.S., Chungbuk National University, Cheongju, Republic of Korea | Jeong, J.H., Chungbuk Province College, Okcheon, Republic of Korea | Nam, S.Y., Chungbuk National University, Cheongju, Republic of Korea | Yun, Y.W., Chungbuk National University, Cheongju, Republic of Korea | Kim, J.S., Chungbuk National University, Cheongju, Republic of Korea | Lee, B.J., Chungbuk National University, Cheongju, Republic of Korea
Colorectal cancer (CRC) is one of the leading causes of cancer death in western countries or in the developed countries. Zinc intake has been associated with decreased risk of CRC. We investigated the effect of zinc on the formation of colonic aberrant crypt foci (ACF) induced by azoxymethane followed by dextran sodium sulfate in mice. Five-week old ICR mice were fed with the different zinc levels (0.01, 0.1, 1 ppm) for 12 weeks. The numbers of ACF were measured in the colonic mucosa. The ACF number of HZn group was significantly low compared with LZn group or MZn group. Cytosolic superoxide dismutase activity was the highest in HZn group, while thiobarbituric acid reactive substance level for lipid peroxidation was the highest in LZn group. There was no difference in number of PCNA-positive proliferative cells among the groups. TUNEL-positive apoptotic cells were increased in HZn group compared with LZn group. The HZn group exhibited a decrease of β-catenin immunostaining areas compared with the LZn or MZn group. These findings indicate that dietary zinc might exert a protecting effect against colon carcinogenesis by inhibiting the development of ACF in the mice.
Показать больше [+] Меньше [-]Role of obioactin on toxoplasmacidal activity within mouse peritoneal macrophages
1994
Yang, M.P. (Chungbuk National University, Cheongju (Korea Republic). College of Veterinary Medicine)
The effects of selenium on fetal growth and development in CD-1 mice exposed with mercury for the gestation period
1994
Kim, J.S. | Lee, S.M. | Lee, W.C. (Konkuk University, Seoul (Korea Republic). Department of Veterinary Medicine) | Choi, S.W. (Chungbuk National University, Cheongju (Korea Republic). College of Veterinary Medicine)
Effects of serum on lymphokines producing capabilities of CD8+ T cells
1994
Ryu, S.Y. | Yoon, W.K. | Cho, S.W. | Kim, M.K. (Chungnam National University, Taejon (Korea Republic). College of Veterinary Medicine) | Kim, T.H. (Korea Cancer Center Hospital, Seoul (Korea Republic). Laboratory of Radiation Medicine)
The cytokinesis-block micronucleus assay as a biological dosimeter in irradiated lymphocyte : comparison of the response of mouse and human
1993
Kim, S.H. | Kim, T.H. | Rue, S.Y. | Koh, J.H. (Korea Cancer Center Hospital, Seoul (Korea Republic). Laboratory of Radiation Medicine) | Cho, C.K. | Koh, K.H. | Yoon, H.K. (Korea Cancer Center Hospital, Seoul (Korea Republic). Department of Therapeutic Radiology) | Choi, S.Y. (Korea Cancer Center Hospital, Seoul (Korea Republic). Laboratory of Epidemiology)
Evaluation of a cell enzyme-linked immunosorbent assay for the detection of borna disease virus antibodies in experimentally infected animals
1992
Lee, D.S. (Cheju National University, Cheju (Korea Republic). Department of Veterinary Medicine)