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Screening of Active Substance FS11052 as an Inhibitor of Neurotransmitter Release From PC12 Cells
2006
Lee, Y.S. (Wonkwang University, Iksan, Republic of Korea) | Lee, J.H. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: johnhlee@chonbuk.ac.kr
We established an in vitro experimental system using the following procedure. We first introduced tritium-labeled norepinephrine ([³H]-NE) into PC12 cells. The [³H]-NE incorporated into PC12 cells were then stimulated by a high concentration (60 mM) of K+ buffer during 12 minutes. Then, we collected 100 μl supernatant and counted the amount of [³H]-NE release from PC12 cells with a scintillation counter. After screening fungal, Streptomyces spp. or bacterial product using this experimental sytem, we obtained FS11052 from Streptomyces spp. which inhibited [³H]-NE release from PC12 cells.
Показать больше [+] Меньше [-]A study on the nonadrenergic noncholinergic neurotransmitters in porcine gastric fundus
1997
Kim, T.W. | Na, J.H. | Lee, J.H. | Yang, I.S. (Seoul National University, Suwon (Korea Republic). College of Veterinary Medicine)
Neuropeptides in the myenteric ganglia and nerve fibres of the forestomach and abomasum of grey, white and black Karakul lambs
1994
Groenewald, H.B. (Pretoria Univ., Onderstepoort (South Africa). Dept. of Anatomy)
Effect of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P on isolated renal artery of rabbit
1994
Kim, J.H. (Gyeongsang National University, Chinju (Korea Republic). College of Veterinary Medicine) | Shim, C.S. (Gyeongnam Animal Health Institute, Yangsan (Korea Republic). Eastern Branch) | Park, S.E. (Gyeongnam Animal Health Institute, Masan (Korea Republic). Central Branch)
