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Effect of preexisting FeLV infection or FeLV and feline immunodeficiency virus coinfection on pathogenicity of the small variant of Haemobartonella felis in cats
2002
George, Jeanne W. | Rideout, Bruce A. | Griffey, Stephen M. | Pedersen, Niels C.
Objective-To investigate the effects of preexisting FeLV infection or FeLV and feline immunodeficiency (FIV) coinfection on the pathogenicity of the small variant of Haemobartonella felis (Hfsm, California variant) in cats. Animals-20 FeLV infected, 5 FeLV-FIV coinfected, and 19 retrovirus-free cats. Procedure-A client-owned cat, coinfected with FeLV and Hfsm, was the source for Hfsm. Inoculum 1 (FeLV free) was obtained by passage of source Hfsm through 4 FeLV-resistant cats. Inoculum 2 was obtained by further passage of Hfsm (inoculum 1) through 2 specific pathogenfree cats. Results-A mild-to-moderate anemia started 21 days after inoculation, with its nadir occurring at 35 to 42 days after inoculation. Infection with Hfsm induced greater decrease in hemoglobin concentration in FeLV infected cats, compared with retrovirus free cats. Reticulocytosis, macrocytosis, and polychromasia of erythrocytes developed in anemic cats regardless of retrovirus infection status. Mean neutrophil counts decreased during the hemolytic episode. For most cats, the anemia was transient. Four FeLV infected cats, 1 of which was also FIV infected, developed fatal FeLV-associated myeloproliferative diseases. Of the surviving cats, 8 died over the next 24 months from other FeLV-related diseases. Hemolysis did not recur after the initial episode. Inoculum 1 induced more severe anemia than inoculum 2. Conclusions and Clinical Relevance-Our results support the clinical observation that cats coinfected with FeLV and H felis develop more severe anemia than cats infected with H felis alone. Infection with Hfsm may induce myeloproliferative disease in FeLV infected cats. The small variant of H felis may lose pathogenicity by passage through FeLV-free cats.
Показать больше [+] Меньше [-]Virulence of South African isolates of Haemophilus paragallinarum. Part 3: experimentally produced NAD-independent isolate
2002
Taole, M. | Albertyn, J. | Van Heerden, E. | Bragg, R.R. (Free State Univ., Bloemfontein (South Africa). Microbiology Dept.)
Virulence of South African isolates of Haemophilus paragallinarum. Part 1: NAD-dependent field isolates
2002
Bragg, R.R. (Free State Univ., Bloemfontein (South Africa). Microbiology and Biochemistry Dept.)
Virulence of South African isolates of Haemophilus paragallinarum. Part 2: Naturally occuring NAD-independent field isolates
2002
Bragg, R.R. (Free State Univ., Bloemfontein (South Africa). Microbiology and Biochemistry Dept.)
