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Estrogenic Effects of endocrine disruptors and establishment of screening methods in mice
2005
Jung, J.Y. (Seoul National University, Seoul, Republic of Korea) | Lee, Y.S. (Seoul National University, Seoul, Republic of Korea), E-mail: leeys@snu.ac.kr
The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovarjectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. Chemicals were DEHP, DBP, BPA and NP, were injected sc once daily with combinations of chemicals treatments for 3 days.
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