Samples of the snails were collected from site in Al-Rasheed distract (30 km) southern ofBaghdad. Isolation, identification and acclimatization to laboratory circumstances made within thelaboratory. Several toxic parameters as NOEL, Threshold, different values of ED and LD weredetermined in this study. The ED50 of S. officinalis and Copper sulfates to B. truncatus were (8.8and0.04g/L) respectively. The LD50 of S. officinalis and Copper sulfates to B. truncatus were (20and 2.2 g/L) respectively.The study showed that the extracts of S. officinalis were less effectivethan CuSO4. The results improved that the toxicity of extracts was dose and time dependent. Thepresent work concluded to ability to use the target extracts in control of snails the middle host ofurinary Schistosomiasis.