The efficacy of 4-methylpyrazole (4-MP) and ethanol as treatment for ethylene glycol (EG) intoxication in cats was compared. Twenty-two cats were assigned at random to 6 experimental groups. Cats of 1 experimental group were given only 4-MP; those of another experimental group were given only EG. Cats of 3 experimental groups were intoxicated with EG and given 4-MP at 0 hour or 2 or 3 hours after EG ingestion, and those of 1 experimental group were given EG and treated with ethanol 3 hours after EG ingestion. Physical, biochemical, hematologic, blood gas, serum and urine EG concentrations, and urinalysis findings were evaluated at 0, 1, 3, 6, 9, 12, 24, 48, and 72 hours, 1 week, and 2 weeks after EG ingestion, or 4-MP treatment in cats of the 4-MP only group. The half-life of EG and percentage of ingested EG excreted unchanged were determined for each group. 4-Methylpyrazole treatment at 0 hour was most effective at preventing metabolism of EG. 4-Methylpyrazole was not effective in preventing development of renal failure when given 2 or 3 hours after EG ingestion. Ethanol given 3 hours after EG ingestion was successful in preventing development of renal dysfunction in 2 of the 6 cats treated 3 hours after EG ingestion. Of the remaining 4 cats treated with ethanol, 2 developed transient renal dysfunction and 2 developed acute oliguric renal failure and were euthanatized. 4-Methylpyrazol given 2 or 3 hours after EG ingestion was less effective in preventing EG metabolism than was ethanol given 3 hours after EG ingestion. Therefore 4-MP, at the dose found to be effective in dogs, cannot be recommended as an alternative to ethanol for treatment of EG intoxication in cats.

Mycoplasma gallisepticum (MG) continues to persist in many commercial layer farms in Korea, resulting in losses in egg production. Bacterins and live attenuated vaccines have been used for the prevention of losses caused by MG. One of these attenuated vaccines, MG 6/85 vaccine has been reported to be safe and efficacious in layers. However, MG 6/85 vaccine has not been evaluated for its safety and its efficacy in any commercial layer in Korea. Six-week-old specific pathogen-free (SPF) chickens were vaccinated with MG 6/85 vaccine by aerosol and were challenged with virulent MG R strain at 4 weeks after vaccination.

Salmonella ecterica subsp. enterica serovar gallinarum (S. gallinarum) is the agent of fowl typhoid, and the 9R vaccine is a commercial live vaccine for the prevention of fowl typhoid. The aim of this study was to assess the safety and immunogenicity of different brands of S. gallinarum 9R vaccine used in commercial laying chickens in Korea. All 9R strains originated from three different brands showed the same pattern in the biochemical and serological properties, and pulsed field gel electrophoresis (PFGE) profile, But there was a difference in rhamnose fermentaion, agglutination with Salmonella group D₁ antiserum and PFGE pattern between 9R vaccine strain and field S. gallinarum isolates. In laboratory and field trials for assessment of safety and immunogenicity of 9R vaccine, all of the three 9R vaccines showed the same safety in commercial laying chickens. In addition, there was a significant difference between the vaccinated and unvaccinated control groupsin mortality and the re-isolation rate of the challenge strain from the tissues (p less than 0.05), and no difference by the brands of 9R vaccine. The results from this study indicated that all three different brands of S. gallinarum 9R vaccine showed highly protection against mortality and organ invasion in commercial laying chickens exposed to virulent strains of S. gallinarum.

In the experiment with swine there was studied the influence of ultra-violet and various doses of narrow-band red radiation on efficiency and safety of animals. It has been established, that efficiency and safety of animal skilled groups in comparison with animals of control group has risen. Use of an ultra-violet and narrow-band red irradiation with frequency rate of inclusion of red light three times has a day allowed to raise average alive mass of young plants of pigs on 2,5 kg or on 9,1% (Р less than 0,01), a daily average gain - on 9,6%(Р less than 0,001) and safety of animals - on 10%

There was carried out the veterinary and sanitary examination of meat of young pigs vaccinated against swine erysipelas by a vaccine of a pilot batch. The meat testing results from animals under investigation show that the used vaccines reveal no negative influence on organoleptic and certain physical-chemical characteristics of meat; and by relative biological value the meat of young pigs at the use of concentrated vaccine of Konev matrix and the depot vaccine against swine erysipelas somewhat surpasses the analogous parameter of meat taken from the intact animals. Meat from animals of all groups is free from food borne toxic infections agents and toxicosis which characterizes it as a quality and safe food product. In the tabular form some physical and chemical and biological indicators of meat from young pigs involved in experiences are presented. | Целью работы явилось проведение ветеринарно-санитарной экспертизы мяса молодняка свиней, вакцинированного против рожи свиней вакциной опытной серии. Полученные результаты исследований мяса от подопытных животных указывают на то, что применяемые вакцины не оказывают отрицательного влияния на его органолептические и некоторые физико-химические показатели, а по показателям относительной биологической ценности мясо молодняка свиней при использовании концентрированной вакцины из матрикса Конева и депонированной вакцины против рожи свиней несколько превосходит аналогичный показатель мяса от интактных животных. Мясо от животных всех групп не содержит возбудителей пищевых токсикоинфекций и токсикозов, что характеризует его как качественный и безопасный пищевой продукт. В табличной форме представлены некоторые физико-химические и биологические показатели мяса от молодняка свиней, задействованных в опытах.