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Effects of concurrent exposure to 3-methylcholanthrene and vitamin A on fetal development in rats
1999
Khlood, El.B.M. (Hokkaido Univ., Sapporo (Japan)) | Miyoshi, H. | Iwata, H. | Kazusaka, A. | Kon, Y. | Hadid, A.H.A. | Moustafe, El.K. | Ghonim, M.H. | Fujita, S.
To investigate the effect of the environmental pollutants, polycyclic aromatic hydrocarbons (PAHs), on retinoic acid-induced teratogenesis, all-trans-retinoic acid (RA) dissolved in corn oil (120 mg/kg) was administered orally to pregnant rats at the 11th day of gestation with and without the prior intraperitoneal treatment with 10 mg/kg 3-methylcholanthrene (3-MC) for 3 days. Dams were killed on the 20th day of pregnancy. The examinations of fetuses revealed that 3-MC barely enough to cause induction of P-450 in pregnant dams had profound embryo-toxic effects: the fetal resorption amounted to - 60% of total number of implantations. The fetuses survived weighed less than the control fetuses. All of RA-treated mothers had fetuses with abnormalities, and the main malformations were absence of tail (100%), caudal and sacral malformations (100%), and cleft palate (42%). Pregnant dams received both 3-MC and RA had a reduced severeness of tail anomaly (33%), while the rest, 67%, had short vestigial tail. Caudal and sacral malformations were detected but at a milder degree. We did not observe cleft palate in this group. The concurrent treatment of dams with 3-MC and RA led to an increased inducibility of cytochrome P-450 and subsequently, CYP1A1 dependent enzyme activity higher than those observed after the injection of 3-MC alone. UDP-glucuronyltransferase activity was also markedly induced in concurrent 3-MC and RA group higher than that in 3-MC alone. We suggest that the induction of P-450 and alteration of metabolic enzyme activities may play an important role in reducing the teratogenic potency of RA. However, RA-treatment did not retard the embryo-toxic effect of 3-MC but rather potentiated
Показать больше [+] Меньше [-]Administration of ethylenethiourea during organogenesis periods in pregnant rats., 1; Effects on teratogenic effects, amino acids and protein concentrations in amniotic fluids
1991
Kim, S.H. (Korea Research Inst. of Chemical Technology, Seoul (Korea Republic)) | Huh, R.S. (Kyungpook National Univ., Taegu (Korea Republic). Coll. of Veterinary Medicine)
Teratogenicity of phenytoin in ICR mouse and antiteratogenic effect of dimethyl sulfoxide
1994
Lee, J.K. | Lee, C.E. | Lee, M.H. | Ryu, P.D. | Cho, M.H. | Sung, H.J. | Park, J.B. (Seoul National University, Suwon (Korea Republic). College of Veterinary Medicine)
