Eight of 10 pony foals reared under helminth-free conditions were inoculated PO with 50 Strongylus vulgaris infective larvae/week for 4 weeks, at which time 1 foal died of acute verminous arteritis. Inoculation of 7 remaining foals continued at 2-week intervals for 20 weeks. Of the 7 foals, 3 were treated with ivermectin (0.2 mg/kg of body weight) in an oral paste formulation at experiment weeks 8, 16, 24; 4 foals were not treated. Two foals were not inoculated or treated and served as controls. After the first ivermectin treatment, ivermectin-treated foals had fewer days (12 +/- 2.9) with rectal temperatures > 38.6 C than did nontreated foals (23.3 +/- 3.8). Mean baseline rectal temperatures were 38 +/- 0.2 C. Adverse clinical reactions to ivermectin treatment were not observed in foals. Foals were euthanatized and necropsied 3 weeks after the last ivermectin treatment (week 24). Ivermectin was effective in reducing S vulgaris arterial larval and intestinal adult parasite numbers by 100% in 3 treated foals. Strongylus vulgaris arterial larvae and/or adults were recovered from all 4 nontreated inoculated foals. One nontreated inoculated foal lacked arterial larvae or active arterial lesions, indicating that protective resistance had developed in this individual. Marked gross and histopathologic lesions typical of chronic S vulgaris infection were observed in the 3 nontreated inoculated foals with arterial larvae. Repeated killing of intra-arterial S vulgaris fourth-stage larvae in ivermectin-treated foals did not exacerbate lesions associated with verminous arteritis or induce unique lesions associated with repeated destruction of arterial larvae. Arterial lesions in treated inoculated foals were markedly reduced and had resolved, compared with those in nontreated inoculated foals.

This study was conducted using auto-skin transplantation for repairing of large skin loss of one front limb in dogs. The study was carried out on 8 clinical cases of dogs that brought to the Veterinary Teaching Hospital, College of Veterinary Medicine, University of Mosul, Mosul, Iraq; from October 2006 to September 2010. These animals underwent severe lacerated necrotic wounds especially at one front limb more than others. A protocol of general anesthesia was conducted by premedication with atropine sulphate, followed by a mixture of xylazine hydrochloride and ketamine hydrochloride. The large skin defect treated by creating a subcutaneous tunnel extended from the thoracic to the abdominal area at the lateral side of the trunk; therefore the naked area of affected limb covered by a new skin successfully from the subcutaneous tunnel. The result revealed that the all flaps healed without partial or total loss. The appearance, texture, and color of the flaps were similar to those of the donor site. The auto-skin transplantation by subcutaneous tunnel considers an effective and alternative method for the treatment of large skin defect of one front limb in dogs.

The study was aimed to evaluate the effect ofchitosan sheets on wound healing process and its activity as a wound dressing materials. Accordingly chitosan sheet was isolated and prepared from the exoskeleton of the native shrimps in Basrah Province. Twenty-four male rabbits were used and two full-thickness circular cuts (2cm in diameter) were made on the dorsal aspect of each rabbit. The healing process was evaluated macroscopically by evaluation of the properties of chitosan sheets on wound in terms of (adherence, absorption, and fluid accumulation) on different intervals (i.e.lSt,3’d,7‘h,and 15"‘ post wounding day). On the other hand the contraction rate in tested liand control wounds were evaluated during different intervals (i.e. at lS‘,3' ,7‘ ,and I5“ post wounding day).The healing process was evaluated microscopically in terms of (infiltration of neutrophils and macrophage infiltration, new blood vessels and fibroblast proliferation and Re—epithelialization). . The result of macroscopic evaluation showed that chitosan sheets were firmly adherent to ' . the wound with underlying mild fluid accumulation during the first three post wounding day. At , the same time the sheets started to disappear and completely absorbed at 7' day after wound breation. The result of the effect of the chitosan sheet on wound contraction demonstrated that the bontraction rate of tested wounds was significantly higher than in control wounds through the lperiod of experiment. In the treated group complete wound closure with contraction rate of 100% was reached at 103‘ post wounding day while the control wounds failed to close completely till the ’ lend of experiment at 15‘ day. The results of microscopic evaluation of wound healing process were demonstrated significant increase (p

The advantages of ventral and flank approaches for ovariohysterectomy (OHE) in terms of wound healing rate when compared to each other are still understudied. The effects of different OHE approaches on the wound healing rates of cats in Selangor, Malaysia were investigated. A total of 50 female cats were randomly included in this study. They were divided into the ventral-approach group (n=25) and the flank approach group (n=25). The wound healing rates and possible complications that could arise from the surgery in all cats were monitored daily from Day 1 until Day 7 post-surgery. Data were analysed using Independent T-test. Overall, the incision site wound healing rate in cats from the flank-approach group was found to be significantly higher (P < 0.05) than in cats from the ventral-approach group (72.55 ± 3.48 % vs. 59.91 ± 3.34 %; mean ± SEM). Complete healing of the incision site was observed in 12 % of cats from the flank-approach group as compared to 8 % of cats from the ventral-approach group. However, 8 % of cats from the ventral approach group had post-surgery complications whereas the flank-approach group had none. Results from the alternative approach may be attributed to reduced accessibility and contamination of the incision site during recovery

A number of studies have measured collagen fibers and collagen&#xD;deposition in wound healing process with advances imaging techniques. However, these are performed by complicated methods and need specific tools. In search of the easier ways in routine histopathological laboratory, collagen measurement and staining pattern of wound healing process were observed in wounded skin of Sprague Dawley’s rat by using two different stains which are standard haematoxylin and eosin (H&E) and modified Masson’s&#xD;trichrome staining (MT). The comparison between these staining in wounded tissues was made to evaluate the advantages and disadvantages of both staining in wound healing study for 21 days postwounding. Tissues which stained with MT staining was then evaluated its collagen re-organization and density by using polarized light microscope with the aid of image analyzer software. Results showed that tissues stained with standard H&E could not be used to measure and differentiate the collagen deposition which is contradictory to MT staining. Wounded tissue stained with MT staining has showed a clear view of collagen fibers deposition&#xD;and re-organisation compared to H&E staining. This finding could validate the using of modified MT staining which leads to accurate histopathological analysis and observation in wound healing study.

Corona Discharge Therapy,an evidence-based therapeutic modality, was used on a 40-year-old female Malaysian elephant. The elephant was on systemic therapy for her wounds for 5 days. All therapies were then stopped for 4 days. Corona Discharge Therapy was subsequently applied on both the hind limb joints for 3 sessions. The non-invasive&#xD;treatment was made with a multi-patented, electronic therapeutic device called VET Sonotron without the concurrent use of drugs. Corona discharge beam (CDB) of the device was used to relieve the joint pain and inflammation. The skin surface of the elephant joints was scanned with the CDB emanating from a discharge electrode to&#xD;which was applied periodic bursts of radio frequency at 0.43 mHz, pulsed at 1 kHz of sound frequency. This therapy showed remarkable anti-inflammatory effects.