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Laparoscopic anatomy of the abdomen in dorsally recumbent horses.
1996
Galuppo L.D. | Snyder J.R. | Pascoe J.R. | Stover S.M. | Morgan R.
Effect of Pasteurella multocida toxin on physeal growth in young pigs.
1996
Ackermann M.R. | Register K.B. | Stabel J.R. | Gwaltney S.M. | Howe T.S. | Rimler R.B.
Effects of tendon grip technique (frozen versus unfrozen) on in vitro surface strain measurements of the equine deep digital flexor tendon.
1996
Matthews G.L. | Keegan K.G. | Graham H.L.
Attempt to pharmacologically modulate procoagulant activity of lipopolysaccharide-stimulated adherent bovine alveolar macrophages.
1996
Olchowy T.W.J. | Dean D.F. | Bochsler P.N.
Epidemiological characteristics of bovine clinical mastitis caused by Staphylococcus aureus and Escherichia coli studied by DNA fingerprinting.
1996
Lam T.J.G.M. | Lipman L.J.A. | Schukken Y.H. | Gaastra W. | Brand A.
Use of force-plate analysis of gait to compare two surgical techniques for treatment of cranial cruciate ligament rupture in dogs.
1996
Jevens D.J. | DeCamp C.E. | Hauptman J. | Braden T.D. | Richter M. | Robinson R.
Attempted transmission of Ehrlichia canis by Rhipicephalus sanguineus after passage in cell culture.
1996
Mathew J.S. | Ewing S.A. | Barker R.W. | Fox J.C. | Dawson J.E. | Warner C.K. | Murphy G.L. | Kocan K.M.
High-speed exercise history and catastrophic racing fracture in Thoroughbreds.
1996
Estberg L. | Stover S.M. | Gardner I.A. | Drake C.M. | Johnson B. | Ardans A.
Pharmacokinetics of caffeine in lactating dairy cows.
1995
DeGraves F.J. | Ruffin D.C. | Duran S.H. | Spano J.S. | Whatley E.M. | Schumacher J. | Riddell M.G.
Because caffeine is metabolized by the hepatic P-450 cytochrome oxidase system, clearance of caffeine is an excellent quantitative test of hepatic function in human beings. It is currently used in much the same way that creatinine clearance is used to assess renal function. Caffeine clearance was measured in lactating dairy cows initially to determine the suitability of caffeine clearance as an indicator of hepatic function in cattle. Pharmacokinetic variables of caffeine were studied in 6 adult lactating dairy cows after IV administration of a single dose of caffeine sodium benzoate (2 mg of caffeine/kg of body weight). Caffeine concentration was analyzed by use of an automated enzyme immunoassay. The lower limit of detection of the assay for caffeine in serum was 0.079 micrograms/ml. Serum caffeine concentration-time curves best fit an open two-compartment pharmacokinetic model. Harmonic mean elimination half-life was 3.8 (range, 2.6 to 6.9) hours, and total clearance was 0.118 (range, 0.090 to 0.197) L/kg/h. Milk caffeine concentration was similar to serum concentration 1.5 to 24 hours after caffeine administration. Adverse effects were not observed in cows given caffeine.
Показать больше [+] Меньше [-]Microorganisms isolated from the corneal surface before and during topical cyclosporine treatment in dogs with keratoconjunctivitis sicca.
1995
Salisbury M.A.R. | Kaswan R.L. | Brown J.
The effect that topical administration of cyclosporine would have on the number and type of microorganisms isolated from the corneal surface of dogs with keratoconjunctivitis sicca was studied. Schirmer tear tests were performed on and corneal swab specimens were collected from 61 eyes of 31 dogs with keratoconjunctivitis sicca prior to and after 3, 6, and 12 months of treatment with cyclosporine. In eyes that responded to cyclosporine treatment (Schirmer tear test value increased by greater than or equal to 5 mm/min, compared with pretreatment value), the percentage of eyes from which bacteria were isolated after 3, 6, and 12 months of treatment was significantly (P < 0.001) less than the percentage from which bacteria were isolated prior to treatment. However, among eyes that did not respond to treatment, we did not detect a significant change over time in prevalence of bacteria or type of bacteria isolated. The percentage of eyes from which fungi were isolated decreased during treatment; however, the small number of eyes in which fungal culture results were initially positive precluded demonstration of a significant change. For all eyes, we did not detect any significant differences over time in the frequency with which specific bacterial genera were isolated, with the exception of beta-hemolytic Streptococcus spp. Opportunistic corneal infections were not detected even though none of the dogs received antibiotics. An increase in production of tears, which contain anti-infection proteins, was believed to be the primary factor responsible for the decrease in the percentage of eyes from which microorganisms could be isolated.
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