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Astragaloside protects rat brain from microwave-induced functional injuries via restoring acetylcholine and normalizing electroencephalogram
2020
Zhao, Li | Sun, Yunbo | Yu, Chao | Chen, Junjun | Xu, Xinping | Zhang, Xueyan | Wang, Hui | Zhang, Jing | Wang, Haoyu | Dong, Ji | Yao, Binwei | Zhou, Hongmei | Liu, Shuchen | Peng, Ruiyun
Studies from our group and others have reported that 30 mW/cm² microwave could damage the structures of rat hippocampus, as well as impair the neuronal functions. The neuroprotective effects of astragaloside, purified from Astragalus membranaceus, have been demonstrated in animal models of neurodegenerative diseases. In this study, we found that 30 mW/cm² microwave impaired spatial learning and memory ability in rats, while astragaloside could significantly alleviate the injuries. The pathological analysis also showed that astragaloside protected neurons from microwave-induced damages, such as mitochondrial swelling and cavitation, rough endoplasmic reticulum swelling and dilation, synaptic gap disappearing, and vesicle aggregation. Moreover, microwave-induced structural damage of synapse resulted in downregulation of acetylcholine, an important neurotransmitter for information transmission, while astragaloside could protect the structure of synapse, as well as restore the acetylcholine level in rat hippocampus. Furthermore, astragaloside also accelerated the recovery of brain electroencephalogram (EEG) after microwave exposure, indicating that astragaloside could promote the normalization of neuronal functions. In conclusion, astragaloside protected the morphological structures and restored acetylcholine level in rat hippocampus, which could improve brain functions via normalizing brain EEG. Therefore, astragaloside might be a promising candidate to treat microwave-induced injuries of central nervous system (CNS).
Показать больше [+] Меньше [-]Gallic acid affects blood-brain barrier permeability, behaviors, hippocampus local EEG, and brain oxidative stress in ischemic rats exposed to dusty particulate matter
2020
Mirshekari Jahangiri, Hamzeh | Sarkaki, Alireza | Farbood, Yaghoob | Dianat, Mahin | Goudarzi, Gholamreza
Dust storms are environmental natural events that transport high concentrations of particulate matter (PM) in living spaces. Recent epidemiological studies have shown that air pollution is associated with stroke. In the present study we aimed to investigate the probable protective effects of gallic acid (GA) on blood-brain barrier (BBB) disruption, brain oxidative stress, anxiety, depression, locomotion behaviors, and changes of hippocampal local electroencephalogram (local EEG) power induced by 4-vessel transient occlusion (4VO I/R) following exposure to dusty PM in rats. Male Wistar rats were divided randomly into eight groups: (1) vehicle+Sham (Veh + Sh), (2) vehicle+4VO I/R (Veh + I/R), (3) gallic acid+sham (GA + Sh), (4) gallic acid+4VO I/R (GA + I/R), (5) vehicle+PM (Veh + PM), (6) PM + 4VO I/R (PM + I/R), (7) gallic acid+PM + Sham (GA + PM + Sh), and (8) gallic acid+PM + 4Vo I/R (GA + PM + I/R). 4VO type of I/R was induced after 10 days of pretreatment by GA 100 mg/kg/2 ml/ip, or 2 ml/kg/ip, normal saline as vehicle (Veh) and exposure to dust storm composed of dusty PM (DPM, 2000–8000 μg/m3), 60 min daily for consecutive 10 days) simultaneously. Seventy-two hours after I/R induction, all behavioral tests and BBB permeability evaluation were done. Hippocampus local EEG was recorded just before and 72 h after I/R induction, and finally brain tissue oxidative stress was assayed. Data showed that 4VO I/R following exposure to DPM increased BBB permeability (p < 0.001), brain oxidative stress (p < 0.001), induced anxiety (p < 0.001), depression (p < 0.01), locomotion impairment (p < 0.001), superoxide dismutase (SOD) activity, and local EEG power also were decreased in PM + Sh (p < 0.001). Pretreatment with GA reversed BBB permeability and MDA. Our findings suggest that GA is a probable protective agent against adverse effects of both I/R and exposure to DPM and also in I/R subjects exposed to DPM. The beneficial effects of GA may induce by its antioxidative and anti-inflammatory properties.
Показать больше [+] Меньше [-]Sources and distribution of 241Am in the vicinity of a deep geologic repository
2019
Thakur, Punam | Ward, Anderson L.
The detection, distribution, and long-term behavior of ²⁴¹Am in the terrestrial environment at the Waste Isolation Pilot Plant (WIPP) site were assessed using historical data from an independent monitoring program conducted by the Carlsbad Environmental Monitoring & Research Center (CEMRC), and its predecessor organization the Environmental Evaluation Group (EEG). An analysis of historical data indicates frequent detections of trace levels of ²⁴¹Am in the WIPP environment. Positive detections and peaks in ²⁴¹Am concentrations in ambient air samples generally occur during the March to June timeframe, which is when strong and gusty winds in the area frequently give rise to blowing dust. A study of long-term measurements of ²⁴¹Am in the WIPP environment suggest that the resuspension of previously contaminated soils is likely the primary source of americium in the ambient air samples from WIPP and its vicinity. Furthermore, the ²⁴¹Am/²³⁹ ⁺ ²⁴⁰Pu ratio in aerosols and soils was reasonably consistent from year to year and was in agreement with the global fallout ratios. Higher than normal activity concentrations of ²⁴¹Am and ²⁴¹Am/²³⁹ ⁺ ²⁴⁰Pu ratios were measured in aerosol samples during 2014 as a result of February 14, 2014 radiation release event from the WIPP underground. However, after a brief spike, the activity concentrations of ²⁴¹Am have returned to the normal background levels. The long-term monitoring data suggest there is no persistent contamination and no lasting increase in radiological contaminants in the region that can be considered significant by any health-based standard.
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