Heavy metal contaminated soil raises major global environmental and agricultural concern. Recently soil pollution through lead (Pb) and chromium (Cr) becoming serious problem and remediation or utilization of those contaminated soil with potential crops is of the outmost importance. The objectives of present study were to examine the effects of Pb and Cr on three different kenaf and mesta varieties for seed germination, seedling establishment and amount of Pb and Cr uptake by tested varieties in laboratory condition. Three varieties were used for the study namely, HC-95 (kenaf), CPL-72126 (mesta) and Samu-93 (mesta) and the treatments were combination of Pb and Cr chemical at (0,0), (60,60), (80,80), (100,100) and (120,120) mg/L. Increased level of lead and chromium gradually reduced the germination percentage and primary growth parameters compared to control. The shoot and root lengths were affected only little, whereas, the biomass showed a considerable reduction with the increase of Pb and Cr toxicity. Stress tolerance indices showed a gradual and negative response by the plant with the increase of metal concentrations. However, in all the levels of Pb and Cr treatment, the seedlings were capable to tolerate the toxicity and seedlings were established. Bioaccumulation of Cr was higher than that of Pb in all varieties and in all treatments. The interaction of Pb and Cr reduced the toxic effect of both metals to the plants. The findings are helpful for selecting fiber crop varieties for cultivation in contaminated soils or phytoremediation of Pb and Cr from the contaminated soils.