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Результаты 1201-1210 из 5,149
COPD rat model is more susceptible to cold stress and PM2.5 exposure and the underlying mechanism Полный текст
2018
Zhang, Kai | Guo, Lei | Wei, Qiaozhen | Song, Quanquan | Liu, Jiangtao | Niu, Jingping | Zhang, Li | Ruan, Ye | Luo, Bin
The purpose of this study is to verify the hypothesis that chronic obstructive pulmonary disease (COPD) model rat is more susceptible to cold stress and fine particulate matter (PM2.5) exposure than the healthy rat, and explore the related mechanism. COPD rat model, established with cigarette smoke and lipopolysaccharide intratracheal instillation, were exposed to cold stress (0 °C) and PM2.5 (0, 3.2, 12.8 mg/ml). After that, the levels of superoxide dismutase, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), monocyte chemotactic protein 1 (MCP-1) and angiotensin Ⅱ (Ang-Ⅱ) in lung were measured, as well as the expression levels of lung 8-hydroxy-2-deoxyguanosine (8-OHdG), nuclear factor kappa B (NF-κB), heme-oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2). There were significant positive relationships between PM2.5 and lung level of iNOS, TNF-α, MCP-1 and Ang-Ⅱ, lung function and pathologic damage in COPD rats. The HO-1, NF-κB and 8-OHdG were found highly expressed in COPD rat lung, particularly at the higher PM2.5 dose of cold stress groups, while Nrf2 was found declined. Thus, COPD rats may be more susceptible to cold stress and PM2.5 exposure. Cold stress may aggravate PM2.5-induced toxic effects in the lung of COPD rats through increasing Ang-Ⅱ/NF-κB signaling pathway and suppressing Nrf2 signaling pathway.
Показать больше [+] Меньше [-]Simulation modeling for a resilience improvement plan for natural disasters in a coastal area Полный текст
2018
Song, Kihwan | You, Soojin | Chon, Jinhyung
Floods are threats to ecosystems that are caused by natural disasters such as typhoons and heavy rain, and to respond to these threats, resilience needs to be improved. In this study, the response of the social-ecological system of Haeundae-gu (Busan, Republic of Korea) to disasters is analyzed by using a causal loop diagram, and a resilience improvement plan is presented by simulating the disaster resilience using green infrastructure through the System Resilience Dynamics Model. First, the resilience values are highest when green infrastructure is applied at the maximum applicable ratio (30%) compared with no application. Second, in the public and private areas of Haeundae-gu, resilience according to green roof scenario was higher until approximately 8 h after the beginning of rainfall, but then the resilience according to infiltration storage facility scenario was higher. In the transportation and industrial areas, the overall resilience according to infiltration storage facility scenario was higher than the resilience according to porous pavement scenario. This study demonstrates that a resilience improvement plan based on simulation can support decision making to respond to disasters such as typhoons.
Показать больше [+] Меньше [-]Prenatal exposure to polychlorinated biphenyl and umbilical cord hormones and birth outcomes in an island population Полный текст
2018
Tang, Mengling | Yin, Shanshan | Zhang, Jianyun | Chen, Kun | Jin, Mingjuan | Liu, Weiping
Prenatal exposure to polychlorinated biphenyl (PCB) is suspected to interfere with fetal development including reproductive and thyroid function and birth outcomes, but published evidence are still sparse. We designed a cross-sectional study to analyze the associations between PCB levels in umbilical cord sera and hormones and birth outcomes of mothers and newborns who are residents from an island. Seven indicator-PCB (PCB-28, 52, 101, 118, 138, 153, 180), and five reproductive hormones including luteotropic hormones (LH), estradiol (E2), testosterone (T), follicle-stimulating hormones (FSH) and anti-Mullerian hormones (AMH), and three thyroid hormones including tri-iodothyronine (T3), tetra-iodothyronine (T4) and thyroid stimulating hormones (TSH) were measured in 106 cord sera specimens. Birth outcomes include birth weight, length, head circumference, and gestational age. Multiple linear regression and quartile regression were used to analyze the associations between PCB and each of the hormones and birth outcomes, adjusting for selected potential confounders. The median value of total PCB in umbilical cord sera was 2.02 μg L−1 (IQR, 1.13–4.64). Several negative associations between PCB exposure and reproductive hormones were found. Among them, the β value of PCB-101 for FSH reached −0.38 (95%CI, −0.69, −0.07; p = 0.02). Moreover, we also found some sex-specific associations i.e. PCB-28 was negatively correlated with LH and T and PCB-118 was negatively correlated with T in male newborns but not in female newborns. The associations between PCB and birth outcomes seem to differ by molecular weight of the PCB congeners i.e. the low-chlorinated PCB congeners were negatively associated with gestational age and head circumference while high-chlorinated PCB congeners were positively associated birth weight and gestational age. In this study, we found that PCB congeners with different molecular weight has different associations with hormones and birth outcomes, and future studies are recommended to investigate underlying mechanisms of these associations.
Показать больше [+] Меньше [-]Comparisons of microplastic pollution between mudflats and sandy beaches in Hong Kong Полный текст
2018
Lo, Hoi-Shing | Xu, Xiaoyu | Wong, Chun-Yuen | Cheung, Siu-Gin
Most of the previous studies of microplastic pollution on coastal habitats focused on high energy beaches although low energy areas such as mudflats are supposed to retain more microplastics, not to mention that mudflats are biologically more diverse. We quantified and characterized microplastics from 10 mudflats and 10 sandy beaches in Hong Kong spanning from the eastern to western waters. Sediment samples were collected at 1.0 m and 1.5 m above chart datum (CD) and at the strandline. Abundance of microplastics ranged between 0.58 and 2116 items kg−1 sediment with that on mudflats being ten times more than on beaches. Polyethylene (46.9%) was the most abundant and followed by polypropylene (13.8%) and polyethylene terephthalate (13.5%). Expanded polystyrene was the most abundant in the strandline samples but not at 1.0 m and 1.5 m above CD. Although previous studies have concluded that the input from Pearl River is a major source of microplastics on Hong Kong shores, this study has demonstrated that the contribution of local pollution sources such as discharge from sewage treatment plants to microplastic pollution should not be neglected.
Показать больше [+] Меньше [-]Insights about sources, distribution, and degradation of sewage and biogenic molecular markers in surficial sediments and suspended particulate matter from a human-impacted subtropical estuary Полный текст
2018
Cabral, Ana Caroline | Martins, César C.
The molecular markers sterols and linear alkylbenzenes (LABs) were analyzed in the surficial sediments and suspended particulate matter (SPM) of a subtropical estuary in South Atlantic (Paranaguá Estuarine System). The purpose of this study was identify the spatial distribution of sewage and the input of biogenic organic matter (OM) and to provide comparative insights about their behavior, compositions, and sources. The concentration of coprostanol ranged from < DL (detection limit) to 2.67 μg g−1 in SPM and from < DL to 0.94 μg g−1 in sediments. Total LABs ranged from 43.8 to 480.0 ng g−1 in SPM and from < DL to 21.0 ng g−1 in sediments. LABs homologs composition varied between the two matrices. The local hydrodynamic pattern may promote water column homogenization, dispersion, and dilution of sewage particles, and preferential sedimentation in fluvial and mixture zones. Results suggest that SPM is a good matrix for larger spatial and short time scale evaluation while sediments may help to define hot spot areas of input and final deposition of sewage particles. Marine sterols predominated in SPM while no dominance patterns of marine/terrestrial sterols occurred in surficial sediments. The higher degradation rates of sterols and LABs in the water column must be the main factor for the sharp drop in concentration towards the sediment and the variation of the preferential composition of these markers between compartments.
Показать больше [+] Меньше [-]Changes of total and freely dissolved polycyclic aromatic hydrocarbons and toxicity of biochars treated with various aging processes Полный текст
2018
Oleszczuk, Patryk | Kołtowski, Michał
The aim of this study was to determine the effect of biochar aging on the content of polycyclic aromatic hydrocarbons (PAHs) (the total content – Ctot, and the freely dissolved – Cfree) in biochar and its ecotoxicity. Two biochars (BCS and BCM) with varying properties were aged for 420 days at different temperatures (−20 °C, 4 °C, 20 °C, 70 °C), at a variable temperature (−20/20 °C), in the presence of nutrients, and in the presence of inoculum and nutrients. After the aging process, Ctot and Cfree PAHs were determined in samples obtained and an ecotoxicological analysis was performed, which involved tests with bacteria (Vibrio fischeri), invertebrates (Folsomia candida) and plants (Lepidium sativum). Aging significantly affected all the parameters tested. The range of changes in the studied parameters depended on the type of biochar and ageing conditions. In the case of most of the aging methods, PAH content (Ctot, Cfree) and toxicity were found to decrease. Aging in the presence of microorganisms and nutrients and in the presence of nutrients alone caused the greatest reduction in Ctot PAH content (a reduction from 30 to 100% relative to non-aged biochar), Cfree PAH content (a reduction from 12 to 100%), root growth inhibition (a reduction from 73 to 90%), and luminescence inhibition (a reduction from 24 to 100%). In the case of Cfree PAHs and toxicity to F. candida, some aging methods caused their increase. The study also found a significant relationship between the changes in Ctot PAH content during aging and inhibition of root growth (BCS, BCM) and inhibition of V. fischerii luminescence (BCM). In no case was a significant correlation (P ≥ 0.05) between Cfree PAHs and the investigated toxicity parameters found.
Показать больше [+] Меньше [-]Modeling of the transport and deposition of polydispersed particles: Effects of hydrodynamics and spatiotemporal evolution of the deposition rate Полный текст
2018
Ma, Enze | Ouahbi, Tariq | Wang, Huaqing | Ahfir, Nasre-Dine | Alem, Abdellah | Hammadi, Ahmed
A time-distance-dependent deposition model is built to investigate the effects of hydrodynamic forces on the transport and deposition of polydispersed particles and the evolution of deposition rates with time and distance. Straining and the heterogeneity of the particle population are considered to play important roles in the decreasing distribution of deposition rates. Numerical simulations were applied in a series of sand column experiments at different fluid velocities for three different porous media. The effects of hydrodynamics forces are elaborated with the systematic variations of deposition dynamic parameters of the proposed model. With retention distributions with particle size as well as temporal and spatial evolutions of deposition rates, the transport and deposition mechanisms of polydispersed particles will be elucidated through the interplay of the variation of the particle size distribution of mobile particle populations and the geometrical change of the porous medium due to retention (straining and blocking).
Показать больше [+] Меньше [-]Occurrence and human exposure to brominated and organophosphorus flame retardants via indoor dust in a Brazilian city Полный текст
2018
Cristale, Joyce | Aragão Belé, Tiago Gomes | Lacorte, Silvia | Rodrigues de Marchi, Mary Rosa
Indoor dust is considered an important human exposure route to flame retardants (FRs), which has arised concern due the toxic properties of some of these substances. In this study, ten organophosphorus flame retardants (OPFRs), eight polybrominated diphenyl ethers (PBDEs) and four new brominated flame retardants (NBFRs) were determined in indoor dust from different places in Araraquara-SP (Brazil). The sampled places included houses, apartments, offices, primary schools and cars. The analysis of the sample extracts was performed by gas chromatography coupled to mass spectrometry and two ionization techniques were used (electron ionization – EI; electron capture negative ionization – ECNI). OPFRs were the most abundant compounds and tris(2-butoxyethyl) phosphate (TBOEP), tris(phenyl) phosphate (TPHP), tris(1,3-dichloroisopropyl) phosphate (TDCIPP) and tris(2-chloroisopropyl) phosphate (TCIPP) were present at the highest concentrations. Among the brominated FRs, the most ubiquitous compounds were BDE-209, bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP) and decabromodiphenyl ethane (DBDPE). Statistical analysis revealed that there were differences among dust typologies for TBOEP, TDCIPP, ethylhexyl diphenyl phosphate (EHDPHP), BDE-209, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB), BEH-TEBP and DBDPE, which were attributed to different construction materials in each particular environment and to the age of the buildings. The highest levels of brominated FRs were observed in offices, TBOEP was at high concentration in primary schools, and TDCIPP was at high concentration in cars. A preliminary risk assessment revealed that toddlers were exposed to TBOEP levels higher than the reference dose when considering the worst case scenario. The results obtained in this study showed for the first time that although Brazil does not regulate the use of FRs, these substances are present in indoor dust at levels similar to the observed in countries that have strict fire safety standards, and that humans are exposed to complex mixtures of these contaminants via indoor dust.
Показать больше [+] Меньше [-]Microplastic and mesoplastic pollution in farmland soils in suburbs of Shanghai, China Полный текст
2018
Liu, Mengting | Lu, Shibo | Song, Yang | Lei, Lili | Hu, Jiani | Lv, Weiwei | Zhou, Wenzong | Cao, Chengjin | Shi, Huahong | Yang, Xiaofeng | He, Defu
Microplastics are emerging pollutants which have been extensively detected in water environments. However, little is known about microplastic pollution in soil environments. In this study, we investigated microplastics and mesoplastics in farmland soils from twenty vegetable fields around the suburbs of Shanghai. In each site, three duplicate soil samples were collected from shallow (0–3 cm) and deep soils (3–6 cm), respectively. Microplastics (sizes of 20 μm - 5 mm) and mesoplastics (5 mm - 2 cm) were detected using methods of density extraction, 30% H₂O₂ digestion and micro-fourier transform infrared spectroscopy. The abundance of microplastics was 78.00 ± 12.91 and 62.50 ± 12.97 items kg⁻¹ in shallow and deep soils, respectively. While, mesoplastics were found with abundance of 6.75 ± 1.51 and 3.25 ± 1.04 items kg⁻¹ in shallow and deep soils. Among these micro(meso)plastics, 48.79% and 59.81% were in size of <1 mm in shallow and deep soils. The main morphotypes of microplastics included fiber, fragment and film, mostly in color of black or transparent. Moreover, we found that topsoil contained higher concentrations and larger sizes of micro(meso)plastics than deep soil. In addition, the vast majority of micro(meso)plastics were polypropylene (50.51%) and polyethylene (43.43%). This study reveals occurrence and characteristics of microplastic pollution in typical farmland soils. It provides important data for subsequent research on microplatics in the terrestrial ecosystem.
Показать больше [+] Меньше [-]Winter haze over North China Plain from 2009 to 2016: Influence of emission and meteorology Полный текст
2018
Zhang, Qianqian | Ma, Qiao | Zhao, Bin | Liu, Xuyan | Wang, Yuxuan | Jia, Beixi | Zhang, Xingying
Analysis of observed PM₂.₅ in Beijing since 2009 reveals that winter haze over North China Plain (NCP) peaked in 2012 and 2013 and there was an improvement in air quality until 2016. The variation of wintertime PM₂.₅ from 2009 to 2016 is influenced by both emission changes and meteorology conditions, and we quantified the relative contributions from these two aspects. Sensitivity simulation by GEOS-Chem suggested that emission reductions over NCP in 2013–2017 caused 10% decrease of regional mean PM₂.₅ concentration in 2016 winter compared to 2012 winter level. We removed emission influence on PM₂.₅ to get PM₂.₅ that influenced by meteorology (met-influenced PM₂.₅). For met-influenced PM₂.₅, compared to original-observed PM₂.₅(the US Embassy data), percentage of clean days (daily PM₂.₅ ≤ 75 μg m⁻³) decreases while that of polluted (75 μg m⁻³ < daily PM₂.₅ ≤150 μg m⁻³) and heavily polluted (150 μg m⁻³ < daily PM₂.₅ ≤ 250 μg m⁻³) days increases. However, proportion of extremely polluted (daily PM₂.₅ > 250 μg m⁻³) days stays unchanged, even if emission reduction is doubled, indicating that the extremely polluted situation over NCP is dominated by meteorological conditions, and emission control from 2013 to 2017 has little effects on the extremely polluted days. We developed an effective haze day index (HDI) to represent the weather conditions conducive to haze days. HDI is constructed based on the normalized near surface meridional wind (V850), temperature difference (δT) between near surface (850 hPa) and upper atmosphere (250 hPa), and the relative humidity at 1000 hPa (RH1000). HDI is skillful to detect 72% of the severe haze days (daily PM₂.₅ > 150 μg m⁻³). On average, the anomalously high V850 is the main cause of severe haze, while in 2012 winter, RH1000 favorable for secondary aerosols’ formation is the largest contributor to haze.
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