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Measurements of underwater noise radiated by commercial ships at a cabled ocean observatory Полный текст
2020
Zhang, Guosong | Forland, Tonje Nesse | Johnsen, Espen | Pedersen, Geir | Dong, Hefeng
Measurements of underwater noise radiated by commercial ships at a cabled ocean observatory Полный текст
2020
Zhang, Guosong | Forland, Tonje Nesse | Johnsen, Espen | Pedersen, Geir | Dong, Hefeng
Measurements of underwater noise radiated under ship normal operations are presented. The acoustic data, from the cabled ocean observatory, are analyzed under each identified ship passage, which was obtained by the Automatic Identification System. Under each passage, sound pressure level is calculated to observe local noise variations due to shipping noise. This paper emphasizes the study of noise variations at the observatory, presents the noise measurements under identified ship passages in the last several years, and provides references for predictive models of underwater noise pollution from commercial ship traffic. From the passages of one ship to the passages of 26 ships, the measurements reveal similar variation patterns when the ships traveled at similar courses, but different patterns when they traveled at different courses. When evaluating the noise variations due to ship traffics, it is important to consider the shipping noise propagation as well as ship movement. | publishedVersion
Показать больше [+] Меньше [-]Measurements of underwater noise radiated by commercial ships at a cabled ocean observatory Полный текст
2020
Zhang, Guosong | Forland, Tonje Nesse | Johnsen, Espen | Pedersen, Geir | Dong, Hefeng
Measurements of underwater noise radiated under ship normal operations are presented. The acoustic data, from the cabled ocean observatory, are analyzed under each identified ship passage, which was obtained by the Automatic Identification System. Under each passage, sound pressure level is calculated to observe local noise variations due to shipping noise. This paper emphasizes the study of noise variations at the observatory, presents the noise measurements under identified ship passages in the last several years, and provides references for predictive models of underwater noise pollution from commercial ship traffic. From the passages of one ship to the passages of 26 ships, the measurements reveal similar variation patterns when the ships traveled at similar courses, but different patterns when they traveled at different courses. When evaluating the noise variations due to ship traffics, it is important to consider the shipping noise propagation as well as ship movement.
Показать больше [+] Меньше [-]The effect of long-term use on the Catch efficiency of Biodegradable gillnets Полный текст
2020
Grimaldo, Eduardo | Herrmann, Bent | Jacques, Nadine | Kubowicz, Stephan | Cerbule, Kristine | Su, Biao | Larsen, Roger B. | Vollstad, Jørgen
The effect of long-term use on the Catch efficiency of Biodegradable gillnets Полный текст
2020
Grimaldo, Eduardo | Herrmann, Bent | Jacques, Nadine | Kubowicz, Stephan | Cerbule, Kristine | Su, Biao | Larsen, Roger B. | Vollstad, Jørgen
The effect of long-term use on the catch efficiency of biodegradable gillnets was investigated during commercial fishing trials and in controlled lab aging tests. The relative catch efficiency between biodegradable and nylon gillnets was evaluated over three consecutive fishing seasons for Atlantic cod (Gadus morhua) in Norway. The biodegradable gillnets progressively lost catch efficiency over time, as they caught 18.4%, 40.2%, and 47.4% fewer fish than the nylon gillnets during the first, second, and third season, respectively. A 1000-hour aging test revealed that both materials began to degrade after just 200 h and that biodegradable gillnets degraded faster than the nylon gillnets. Infrared spectroscopy revealed that the chemical structure of the biodegradable polymer changed more than the nylon. Although less catch efficient than nylon gillnets, biodegradable gillnets have great potential for reducing both capture in lost fishing gear and plastic pollution at sea, which are major problems in fisheries worldwide. | publishedVersion
Показать больше [+] Меньше [-]The effect of long-term use on the catch efficiency of biodegradable gillnets Полный текст
2020
Grimaldo, Eduardo | Herrmann, Bent | Jacques, Nadine | Kubowicz, Stephan | Cerbule, Kristine | Su, Biao | Larsen, Roger | Vollstad, Jørgen
The effect of long-term use on the catch efficiency of biodegradable gillnets was investigated during commercial fishing trials and in controlled lab aging tests. The relative catch efficiency between biodegradable and nylon gillnets was evaluated over three consecutive fishing seasons for Atlantic cod (Gadus morhua) in Norway. The biodegradable gillnets progressively lost catch efficiency over time, as they caught 18.4%, 40.2%, and 47.4% fewer fish than the nylon gillnets during the first, second, and third season, respectively. A 1000-hour aging test revealed that both materials began to degrade after just 200 h and that biodegradable gillnets degraded faster than the nylon gillnets. Infrared spectroscopy revealed that the chemical structure of the biodegradable polymer changed more than the nylon. Although less catch efficient than nylon gillnets, biodegradable gillnets have great potential for reducing both capture in lost fishing gear and plastic pollution at sea, which are major problems in fisheries worldwide.
Показать больше [+] Меньше [-]The effect of long-term use on the Catch efficiency of Biodegradable gillnets Полный текст
2020
Grimaldo, Eduardo | Herrmann, Bent | Jacques, Nadine | Kubowicz, Stephan | Cerbule, Kristine | Su, Biao | Larsen, Roger B. | Vollstad, Jørgen
The effect of long-term use on the catch efficiency of biodegradable gillnets was investigated during commercial fishing trials and in controlled lab aging tests. The relative catch efficiency between biodegradable and nylon gillnets was evaluated over three consecutive fishing seasons for Atlantic cod (Gadus morhua) in Norway. The biodegradable gillnets progressively lost catch efficiency over time, as they caught 18.4%, 40.2%, and 47.4% fewer fish than the nylon gillnets during the first, second, and third season, respectively. A 1000-hour aging test revealed that both materials began to degrade after just 200 h and that biodegradable gillnets degraded faster than the nylon gillnets. Infrared spectroscopy revealed that the chemical structure of the biodegradable polymer changed more than the nylon. Although less catch efficient than nylon gillnets, biodegradable gillnets have great potential for reducing both capture in lost fishing gear and plastic pollution at sea, which are major problems in fisheries worldwide.
Показать больше [+] Меньше [-]Development of a flux DMT with integrated adsorptive stripping voltammetry for free metal ions detection in solution Полный текст
2018
Janot, Noemie | Rotureau, Elise | Pinheiro, Jose Paulo
Development of a flux DMT with integrated adsorptive stripping voltammetry for free metal ions detection in solution. Interfaces Against Pollution
Показать больше [+] Меньше [-]Solid-solution partitioning of Rare Earth Elements in mine-tailings and soils in China: experimental results and multi-surface modelling Полный текст
2018
Janot, Noemie | Huot, Hermine | Otero-Fariña, Alba | Leguédois, Sophie | Groenenberg, Jan E.
Solid-solution partitioning of Rare Earth Elements in mine-tailings and soils in China: experimental results and multi-surface modelling. Interfaces Against Pollution
Показать больше [+] Меньше [-]An ex ante life cycle assessment of wheat with high biological nitrification inhibition capacity Полный текст
2022
Leon, Ai | Guntur Venkata Subbarao | Kishii, Masahiro | Naruo Matsumoto | Kruseman, Gideon K.
It is essential to increase food production to meet the projected population increase while reducing environmental loads. Biological nitrification inhibition (BNI)-enabled wheat genetic stocks are under development through chromosome engineering by transferring chromosomal regions carrying the BNI trait from a wild relative (Leymus racemosus (Lam.) Tzvelev) into elite wheat varieties; field evaluation of these newly developed BNI-wheat varieties has started. Ten years from now, BNI-enabled elite wheat varieties are expected to be deployed in wheat production systems. This study aims to evaluate the impacts of introducing these novel genetic solutions on life cycle greenhouse gas (LC-GHG) emissions, nitrogen (N) fertilizer application rates and N-use efficiency (NUE). Scenarios were developed based on evidence of nitrification inhibition and nitrous oxide (N2O) emission reduction by BNI crops and by synthetic nitrification inhibitors (SNIs), as both BNI-wheat and SNIs slow the nitrification process. Scenarios including BNI-wheat will inhibit nitrification by 30% by 2030 and 40% by 2050. It was assumed that N fertilizer application rates can potentially be reduced, as N losses through N2O emissions, leaching and runoff are expected to be lower. The results show that the impacts from BNI-wheat with 40% nitrification inhibition by 2050 are assessed to be positive: a 15.0% reduction in N fertilization, a 15.9% reduction in LC-GHG emissions, and a 16.7% improvement in NUE at the farm level. An increase in ammonia volatilization had little influence on the reduction in LC-GHG emissions. The GHG emissions associated with N fertilizer production and soil N2O emissions can be reduced between 7.3 and 9.5% across the wheat-harvested area worldwide by BNI-wheat with 30% and 40% nitrification inhibition, respectively. However, the present study recommends further technological developments (e.g. further developments in BNI-wheat and the development of more powerful SNIs) to reduce environmental impacts while improving wheat production to meet the increasing worldwide demand.
Показать больше [+] Меньше [-]A review on occurrence of emerging pollutants in waters of the MENA region Полный текст
2021
Haddaoui, I. | Mateo-Sagasta, Javier
Little is known about the occurrence of emerging pollutants (EPs) in waters in the Middle East and North Africa (MENA) region despite the extensive use of low-quality water there. Available data dealing with the sources, occurrence and removal of EPs within the MENA region in different categories of water is collected, presented and analyzed in this literature review. According to the collected database, the occurrence and removal efficiency of EPs in the water matrix in the MENA region is available, respectively, for 13 and six countries of the 18 in total; no available data is registered for the rest. Altogether, 290 EPs have been observed in different water matrices across the MENA countries, stemming mainly from industrial effluents, agricultural practices, and discharge or reuse of treated wastewater (TWW). Pharmaceutical compounds figure among the most frequently reported compounds in wastewater, TWW, surface water, and drinking water. Nevertheless, pesticides are the most frequently detected pollutants in groundwater. Worryingly, 57 cases of EPs have been reported in different fresh and drinking waters, exceeding World Health Organization (WHO) and European Commission (EC) thresholds. Overall, pharmaceuticals, organic compounds, and pesticides are the most concerning EP groups. The review revealed the ineffectiveness of treatment processes used in the region to remove EPs. Negative removals of some EPs such as carbamazepine, erythromycin, and sulfamethoxazole were recorded, suggesting their possible accumulation or release during treatment. This underlines the need to set in place and strengthen control measures, treatment procedures, standards, and policies for such pollutants in the region.
Показать больше [+] Меньше [-]A comprehensive assessment of endocrine-disrupting chemicals in an Indian food basket: Levels, dietary intakes, and comparison with European data Полный текст
2021
Sharma, Brij Mohan | Bharat, Girija K. | Chakraborty, Paromita | Martiník, Jakub | Audy, Ondřej | Kukučka, Petr | Přibylová, Petra | Kukreti, Praveen Kumar | Sharma, Anežka | Kalina, Jiří | Steindal, Eirik Hovland | Nizzetto, Luca
A comprehensive assessment of endocrine-disrupting chemicals in an Indian food basket: Levels, dietary intakes, and comparison with European data Полный текст
2021
Sharma, Brij Mohan | Bharat, Girija K. | Chakraborty, Paromita | Martiník, Jakub | Audy, Ondřej | Kukučka, Petr | Přibylová, Petra | Kukreti, Praveen Kumar | Sharma, Anežka | Kalina, Jiří | Steindal, Eirik Hovland | Nizzetto, Luca
Endocrine-disrupting chemicals (EDCs) in diet are a health concern and their monitoring in food has been introduced in the European Union. In developing countries, EDC dietary exposure data are scarce, especially from areas perceived as pollution hotspots, including industrialized countries like India. Several persistent organic pollutants (POPs) act as EDCs and pose a pressure to human health mainly through dietary exposure. In the present study a range of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dioxins and furans were measured in several food items collected in an Indian urban (Delhi) and a rural area (Dehradun). Food basket contamination data were used to estimate dietary exposure and compare it with that of the average European population estimated from available monitoring data. All targeted contaminants were found in most food items, especially in dairies and meat products. OCPs were the main contributors. Food supplied to Delhi's markets had higher contamination than that supplied to the peri-urban market in Dehradun. Despite looser control and restrictions, Indian dietary exposure of OCPs and PBDEs were comparable with that of Europe and were lower for PCBs and dioxins. Higher meat consumption in Europe only partly explained this pattern which was driven also by the higher residues in some European food items. A substantial part of endocrine disrupting potential in the diet derives from food and animal feeds internationally traded between developed and developing countries. With increasingly globalized food systems, internationally harmonized policies on EDC in food can lead to better protection of health in both these contexts. | publishedVersion
Показать больше [+] Меньше [-]A comprehensive assessment of endocrine-disrupting chemicals in an Indian food basket: Levels, dietary intakes, and comparison with European data Полный текст
2021
Sharma, Brij Mohan | Bharat, Girija K. | Chakraborty, Paromita | Martiník, Jakub | Audy, Ondřej | Kukučka, Petr | Přibylová, Petra | Kukreti, Praveen Kumar | Sharma, Anežka | Kalina, Jiří | Steindal, Eirik Hovland | Nizzetto, Luca
Endocrine-disrupting chemicals (EDCs) in diet are a health concern and their monitoring in food has been introduced in the European Union. In developing countries, EDC dietary exposure data are scarce, especially from areas perceived as pollution hotspots, including industrialized countries like India. Several persistent organic pollutants (POPs) act as EDCs and pose a pressure to human health mainly through dietary exposure. In the present study, a range of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dioxins and furans were measured in several food items collected from Indian urban (Delhi) and peri-urban (Dehradun) areas. Food basket contamination data were used to estimate EDC dietary exposure and compare it with that of the average European population estimated from available monitoring data. All the target contaminants were found in most food items, especially in dairies and meat products. OCPs were the main contributers to the measured EDC contamination. Food supplied to Delhi's markets had higher EDC contamination than that supplied to the peri-urban market in Dehradun. Despite lax compliance and control measures, Indian dietary exposure of OCPs and PBDEs were comparable with that of Europe and were lower for PCBs and dioxins. Higher meat consumption in Europe only partly explained this pattern which was driven also by the higher EDC residues in some European food items. A substantial part of endocrine disrupting potential in the diet derives from food and animal feeds internationally traded between developed and developing countries. With increasingly globalized food systems, internationally harmonized policies on EDC content in food can lead to better protection of health in both these contexts.
Показать больше [+] Меньше [-]A comprehensive assessment of endocrine-disrupting chemicals in an Indian food basket: Levels, dietary intakes, and comparison with European data Полный текст
2021
Sharma, Brij Mohan | Bharat, Girija K. | Chakraborty, Paromita | Martiník, Jakub | Audy, Ondřej | Kukučka, Petr | Přibylová, Petra | Kukreti, Praveen Kumar | Sharma, Anežka | Kalina, Jiří | Steindal, Eirik Hovland | Nizzetto, Luca
Endocrine-disrupting chemicals (EDCs) in diet are a health concern and their monitoring in food has been introduced in the European Union. In developing countries, EDC dietary exposure data are scarce, especially from areas perceived as pollution hotspots, including industrialized countries like India. Several persistent organic pollutants (POPs) act as EDCs and pose a pressure to human health mainly through dietary exposure. In the present study a range of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), dioxins and furans were measured in several food items collected in an Indian urban (Delhi) and a rural area (Dehradun). Food basket contamination data were used to estimate dietary exposure and compare it with that of the average European population estimated from available monitoring data. All targeted contaminants were found in most food items, especially in dairies and meat products. OCPs were the main contributors. Food supplied to Delhi's markets had higher contamination than that supplied to the peri-urban market in Dehradun. Despite looser control and restrictions, Indian dietary exposure of OCPs and PBDEs were comparable with that of Europe and were lower for PCBs and dioxins. Higher meat consumption in Europe only partly explained this pattern which was driven also by the higher residues in some European food items. A substantial part of endocrine disrupting potential in the diet derives from food and animal feeds internationally traded between developed and developing countries. With increasingly globalized food systems, internationally harmonized policies on EDC in food can lead to better protection of health in both these contexts. | publishedVersion
Показать больше [+] Меньше [-]First measurement of human exposure to current use pesticides (CUPs) in the atmosphere of central Chile: The case study of Mauco cohort Полный текст
2020
Cortés, Sandra | Pozo, Karla | Llanos, Yasna | Martínez, Natalia | Foerster, Claudia | Leiva, Cinthya | Ustáriz, Javier | Přibylová, Petra | Klánová, Jana | Jorquera, Héctor
Chile is a leading agricultural producer and thus consumer of insecticides, herbicides, and fungicides. In Molina, Central Chile, a prospective cohort has been established for studying the incidence and risk factors of chronic diseases in the adult population. Our goals were to measure airborne current use pesticides (CUPs), assess their spatial distribution and potential sources, and estimate health risks for the population in Molina. CUPs were measured using passive air samplers (PAS), deployed on six sites from October 2015 to August 2016. Thirty-eight pesticides were analyzed using high performance liquid chromatography (HPLC), but only nine of them were detected. Chlorpyrifos (CPF) was detected with air concentrations ranging from 444 to 14 624 (pg m(-3)). Diazinon, atrazine, dimethoate, metolachlor, simazine, terbuthylazine and tebuconazole were also detected; only pendimethalin had concentrations as high as those of CPF, with a maximum of 14 927 (pg m(-3)). Backward wind trajectories were used to estimate locations of potential sources contributing to airborne CUPs concentrations. Most of the exposure to CUPs was associated with local sources, while regional sources southern/eastern/western of Molina appear to contribute as secondary sources (soil evaporation followed by atmospheric transport) in spring and summer seasons. A health risk assessment using US-EPA's methodology was carried out for inhalation exposure of detected pesticides. None of the measured CUPs were associated with a hazard quotient (HQ) greater than 1, indicating no significant risk due to inhalation of pesticides in Molina's population with the exception of the group of children below 12 years old. However, further investigations are needed to evaluate others CUPs exposure route such as food consumption and dermal exposure to improve our health risk estimations. | Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) 15130011-15110020 180078 1161673 Vicerrectoria de Investigacion, Pontificia Universidad Catolica de Chile 9/2014 RECETOX Research Infrastructure LM2015051 CZ.02.1.01/0.0/0.0/16_013/0001761
Показать больше [+] Меньше [-]Ecotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids Полный текст
2017
Gismondi, Eric | Thomé, Jean-Pierre | Urien, Nastassia | Uher, Emmanuelle | Baiwir, Dominique | Mazzucchelli, Gabriel | De Pauw, Edwin | Fechner, Lise | Lebrun, Jérémie | FOCUS - Freshwater and OCeanic science Unit of reSearch - ULiège
Ecotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids Полный текст
2017
Gismondi, Eric | Thomé, Jean-Pierre | Urien, Nastassia | Uher, Emmanuelle | Baiwir, Dominique | Mazzucchelli, Gabriel | De Pauw, Edwin | Fechner, Lise | Lebrun, Jérémie | FOCUS - Freshwater and OCeanic science Unit of reSearch - ULiège
peer reviewed | Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health of aquatic organisms. In this study, an ecotoxicoproteomic approach was used to assess the integrated response and possible acclimation mechanisms in Gammarus fossarum following chronic exposures to Cd, Cu or Pb, at environmentally realistic concentrations (i.e. 0.25, 1.5 and 5 µg/L respectively). After 10-week exposure, changes in protein expression were investigated in caeca of control and exposed males. Gel-free proteomic analyses allowed for the identification of 35 proteins involved in various biological functions, for which 23 were significantly deregulated by metal exposures. The protein deregulation profiles were specific to each metal, providing evidence for metal-specific action sites and responses of gammarids. Among the tested metals, Cu was the most toxic in terms of mortality, probably linked with persistent oxidative stress. Moulting and osmoregulation were the major biological functions affected by Cu in the long-term. In Pb-exposed gammarids, significant deregulations of proteins involved in immune response and cytoskeleton were observed. Reproduction appears to be strongly affected in gammarids chronically exposed to Cd or Pb. Besides, modified expressions of several proteins involved in energy transfer and metabolism highlighted important energetic reshuffling to cope with chronic metal exposures. These results support the fact that metallic pressures induce a functional and energetic cost for individuals of G. fossarum with potential repercussions on population dynamics. Furthermore, this ecotoxicoproteomic study offers promising lines of enquiry in the development of new biomarkers that could make evidence of long-term impacts of metals on the health of organisms.
Показать больше [+] Меньше [-]Ecotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids Полный текст
2017
Gismondi, E. | Thomé, J.-P. | Urien, N. | Uher, E. | Baiwir, D. | Mazzucchelli, G. | De Pauw, E. | Fechner, L.C. | Lebrun, J.D.
Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health of aquatic organisms. In this study, an ecotoxicoproteomic approach was used to assess the integrated response and possible acclimation mechanisms in Gammarus fossarum following chronic exposures to Cd, Cu or Pb, at environmentally realistic concentrations (i.e. 0.25, 1.5 and 5 μg/L respectively). After 10-week exposure, changes in protein expression were investigated in caeca of control and exposed males. Gel-free proteomic analyses allowed for the identification of 35 proteins involved in various biological functions, for which 23 were significantly deregulated by metal exposures. The protein deregulation profiles were specific to each metal, providing evidence for metal-specific action sites and responses of gammarids. Among the tested metals, Cu was the most toxic in terms of mortality, probably linked with persistent oxidative stress. Moulting and osmoregulation were the major biological functions affected by Cu in the long-term. In Pb-exposed gammarids, significant deregulations of proteins involved in immune response and cytoskeleton were observed. Reproduction appears to be strongly affected in gammarids chronically exposed to Cd or Pb. Besides, modified expressions of several proteins involved in energy transfer and metabolism highlighted important energetic reshuffling to cope with chronic metal exposures. These results support the fact that metallic pressures induce a functional and energetic cost for individuals of G. fossarum with potential repercussions on population dynamics. Furthermore, this ecotoxicoproteomic study offers promising lines of enquiry in the development of new biomarkers that could make evidence of long-term impacts of metals on the health of organisms.
Показать больше [+] Меньше [-]Ecotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids Полный текст
2017
Gismondi, E. | Thomé, J.-P. | Urien, N. | Uher, E. | Baiwir, D. | Mazzucchelli, G. | de Pauw, E. | Fechner, L.C. | Lebrun, Jérémie, D. | Freshwater and Oceanic Sciences Unit of reSearch (FOCUS) ; Laboratory of Oceanology ; Université de Liège-Université de Liège | Laboratory of Animal Ecology and Ecotoxicity (LEAE-CART) ; Université de Liège | Université de Liège | Hydrosystèmes et Bioprocédés (UR HBAN) ; Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA) | Mass Spectrometry Laboratory (MS LAB) ; Université de Liège-Centre d'Analyse des Résidus en Traces-Groupe Interdisciplinaire de Génoprotéomique Appliquée
Ecotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids Полный текст
2017
Gismondi, Éric | Thomé, Jean-Pierre | Urien, Nastassia | Uher, Emmanuelle | Baiwir, Dominique | Mazzucchelli, Gabriel | de Pauw, Edwin | Fechner, Lise, C. | Lebrun, Jérémie, D. | Laboratoire des Interactions Ecotoxicologie, Biodiversité, Ecosystèmes (LIEBE) ; Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS) | Hydrosystèmes et Bioprocédés (UR HBAN) ; Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA) | Institut National de la Recherche Scientifique [Québec] (INRS) | Fédération Île-de-France de Recherche sur l'Environnement (FIRE) ; Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Mass Spectrometry Laboratory (MS LAB) ; Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège)-Centre d'Analyse des Résidus en Traces-Groupe Interdisciplinaire de Génoprotéomique Appliquée | Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) | ANR-12-ADAP-0003,SequAdapt,Conséquences et mécanismes de l'adaptation à la contamination chimique en Seine(2012)
International audience
Показать больше [+] Меньше [-]Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated dephenyl ethers (PBDEs) in marine mammals Полный текст
2012
Weijs, Liesbeth | Covaci, Adrian | Yang, Raymond S H | Das, Krishna | Blust, Ronny
peer reviewed | Due to migration of harbour porpoises towards more polluted areas like the North Sea and their sensitivity towards pollution, there is a need for proper conservation measures for this species. As a consequence, knowledge about the pollutant’s kinetics is required. The present study is the first to investigate the kinetics of PBDEs in marine mammals using PBPK modeling as a non-destructive tool for describing the chemical’s kinetics in a protected animal species. The models were developed and parameterized using data from the literature and Black Sea harbour porpoises through computer opti- mization. The predictability of these models in time was assessed by reverse dosimetry modeling using data from North Sea porpoises (1990e2008). From these predictions, PBDE 99 levels were found to decrease the fastest, followed by PBDE 153, 47 and 100. Results show that the PBPK models can be applied for harbour porpoises from different regions and also simulate time trends.
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