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Результаты 1921-1930 из 7,995
Selenium(Ⅳ) alleviates chromium(Ⅵ)-induced toxicity in the green alga Chlamydomonas reinhardtii Полный текст
2021
Zhang, Baolong | Duan, Guangqian | Fang, Yingying | Deng, Xuan | Yin, Yongguang | Huang, Kaiyao
The wide range of industrial applications of chromium (Cr) has led to an increasing risk of water contamination by Cr(Ⅵ). However, efficient methods to remove or decrease the toxicity of Cr(Ⅵ) in situ are lacking. The main aim of this study was to investigate the mechanisms by which selenite alleviates chromium(Ⅵ)-induced toxicity in Chlamydomonas reinhardtii. Our results showed that K₂Cr₂O₇ had toxic effects on both the structure and physiology of C. reinhardtii in a dose-dependent manner. Adding selenite significantly alleviated chromium accumulation and toxicity in cells. RNA-seq data showed that the expression level of selenoproteins such as SELENOH was significantly increased. Both SELENOH-amiRNA knockdown mutants and selenoh insertional mutant produced more reactive oxygen species (ROS) and grew slower than the wild type, suggesting that SELENOH can reduce chromium toxicity by decreasing the levels of ROS produced by Cr(Ⅵ). We also demonstrated that selenite can reduce the absorption of Cr(Ⅵ) by cells but does not affect the process of Cr(Ⅵ) adsorption and efflux. This information on the molecular mechanism by which selenite alleviates Cr(Ⅵ) toxicity can be used to increase the bioremediation capacity of algae and reduce the human health risks associated with Cr(Ⅵ) toxicity.
Показать больше [+] Меньше [-]Distribution and toxicity of persistent organic pollutants and methoxylated polybrominated diphenylethers in different tissues of the green turtle Chelonia mydas Полный текст
2021
Weltmeyer, Antonia | Dogruer, Gülsah | Hollert, Henner | Ouellet, Jacob D. | Townsend, Kathy | Covaci, Adrian | Weijs, Liesbeth
Investigating environmental pollution is important to understand its impact on endangered species such as green turtles (Chelonia mydas). In this study, we investigated the accumulation and potential toxicity of selected persistent organic pollutants (POPs) and naturally occurring MeO-PBDEs in liver, fat, kidney and muscle of turtles (n = 30) of different gender, size, year of death, location and health status. Overall, POP concentrations were low and accumulation was highest in liver and lowest in fat which is likely due to the poor health of several animals, causing a remobilization of lipids and associated compounds. PCBs and p,p’-DDE dominated the POP profiles, and relatively high MeO-PBDE concentrations (2′-MeO-BDE 68 up to 192 ng/g lw, 6-MeO-BDE 47 up to 79 ng/g lw) were detected in all tissues. Only few influences of factors such as age, gender and location were found. While concentrations were low compared to other marine wildlife, biological toxicity equivalences obtained by screening the tissue extracts using the micro-EROD assay ranged from 2.8 to 356 pg/g and the highest values were observed in muscle, followed by kidney and liver. This emphazises that pollutant mixtures found in the turtles have the potential to cause dioxin-like effects in these animals and that dioxin-like compounds should not be overlooked in future studies.
Показать больше [+] Меньше [-]Risk of gastric cancer in the environs of industrial facilities in the MCC-Spain study Полный текст
2021
García-Pérez, Javier | Lope, Virginia | Fernández de Larrea-Baz, Nerea | Molina, Antonio J. | Tardón, Adonina | Alguacil, Juan | Pérez-Gómez, Beatriz | Moreno, Víctor | Guevara, Marcela | Castaño-Vinyals, Gemma | Jiménez-Moleón, José J. | Gómez Acebo, Inés | Molina-Barceló, Ana | Martín Hernández, Vicente | Kogevinas, Manolis | Pollán, Marina | Aragonés, Nuria
Gastric cancer is the fifth most frequent tumor worldwide. In Spain, it presents a large geographic variability in incidence, suggesting a possible role of environmental factors in its etiology. Therefore, epidemiologic research focused on environmental exposures is necessary.To assess the association between risk of gastric cancer (by histological type and tumor site) and residential proximity to industrial installations, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer conducted in Spain (MCC-Spain).In this study, 2664 controls and 137 gastric cancer cases from 9 provinces, frequency matched by province of residence, age, and sex were included. Distances from the individuals’ residences to the 106 industries located in the study areas were computed. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industries, adjusting for matching variables and potential confounders.Overall, no excess risk of gastric cancer was observed in people living close to the industrial installations, with ORs ranging from 0.73 (at ≤2.5 km) to 0.93 (at ≤1.5 km). However, by industrial sector, excess risks (OR; 95%CI) were found near organic chemical industry (3.51; 1.42–8.69 at ≤2 km), inorganic chemical industry (3.33; 1.12–9.85 at ≤2 km), food/beverage sector (2.48; 1.12–5.50 at ≤2 km), and surface treatment using organic solvents (3.59; 1.40–9.22 at ≤3 km). By specific pollutant, a statistically significant excess risk (OR; 95%CI) was found near (≤3 km) industries releasing nonylphenol (6.43; 2.30–17.97) and antimony (4.82; 1.94–12.01).The results suggest no association between risk of gastric cancer and living in the proximity to the industrial facilities as a whole. However, a few associations were detected near some industrial sectors and installations releasing specific pollutants.
Показать больше [+] Меньше [-]Application of surface complexation modeling on adsorption of uranium at water-solid interface: A review Полный текст
2021
Sun, Yubing | Li, Ying
Precise prediction of uranium adsorption at water-mineral interface is of great significance for the safe disposal of radionuclides in geologic environments. Surface complexation modeling (SCM) as a very useful tool has been extensively investigated for simulating adsorption behavior of metals/metalloids at water-mineral interface. Numerous studies concerning the fitting of uranium adsorption on various adsorbents using SCM are well documented, but the systematic and comprehensive review of uranium adsorption using various SCM is not available. In this review, we briefly summarized the rationale of SCM, including constant-capacitance-model (CCM), diffuse-layer-model (DLM), triple-layer-model (TLM); The recent progress in the application of SCM on the fitting of uranium adsorption towards metal (hydr)oxides, clay minerals and soil/sediments was reviewed in details. This review hopefully provides the beneficial guidelines for predicting the transport and fate of uranium in geologic environments beyond laboratory timescales.
Показать больше [+] Меньше [-]Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells Полный текст
2021
Wei, Zejing | Nie, Gaohui | Yang, Fan | Pi, Shaoxing | Wang, Chang | Cao, Huabin | Guo, Xiaoquan | Liu, Ping | Li, Guyue | Hu, Guoliang | Zhang, Caiying
Cadmium (Cd) is an occupational and environmental pollutant, which mainly causes nephrotoxicity by damaging renal proximal tubular cells. To evaluate the effects of Cd on pyroptosis and the relationship between pyroptosis and apoptosis in duck renal tubular epithelial cells, the cells were cultured with 3CdSO₄·8H₂O (0, 2.5, 5.0, or 10.0 μM Cd), N-acetyl-L-cysteine (NAC) (100.0 μM), Z-YVAD-FMK (10.0 μM) or the combination of Cd and NAC or Z-YVAD-FMK for 12 h, and then cytotoxicity was assessed. The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1β (IL-1β), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level. Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1β and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels. Additionally, NAC notably improved the changes of above indicators induced by Cd. Combined treatment with Cd and Z-YVAD-FMK remarkably elevated Bcl-2 mRNA and protein levels, inhibited p53, Bax, Bak-1, Cyt C, Caspase-9 and Caspase-3 mRNA levels and p53, Bax, Bak-1, Caspase-9/cleaved Caspase-9 and Caspase-3/cleaved Caspase-3 protein levels, increased mitochondrial membrane potential (MMP), decreased apoptosis ratio and cell damage compared to treatment with Cd alone. Taken together, Cd exposure induces duck renal tubular epithelial cell pyroptosis through ROS/NLRP3/Caspase-1 signaling pathway, and inhibiting Caspase-1 dependent pyroptosis attenuates Cd-induced apoptosis.
Показать больше [+] Меньше [-]Novel brominated flame retardants (NBFRs) in soil and moss in Mt. Shergyla, southeast Tibetan Plateau: Occurrence, distribution and influencing factors Полный текст
2021
Xian, Hao | Hao, Yanfen | Lv, Jingya | Wang, Chu | Zuo, Peijie | Pei, Zhiguo | Li, Yingming | Yang, Ruiqiang | Zhang, Qinghua | Jiang, Guibin
Research on the environmental fate and behavior of novel brominated flame retardants (NBFRs) remains limited, especially in the remote alpine regions. In this study, the concentrations and distributions of NBFRs were investigated in soils and mosses collected from two slopes of Shergyla in the southeast of the Tibetan Plateau (TP), to unravel the environmental behaviors of NBFRs in this background area. The total NBFR concentrations (∑₇NBFRs) ranged from 34.2 to 879 pg/g dw in soil and from 72.8 to 2505 pg/g dw in moss. ∑₇NBFRs in soil samples collected in 2019 were significantly higher than those in 2012 (p < 0.05). Decabromodiphenyl ethane (DBDPE) was the predominant NBFR, accounting for 90% of ∑₇NBFRs on average. The ratio of the concentrations in moss and soil showed significantly positive correlations with LogKOA except for DBDPE (p < 0.05), indicating that the role of mosses as accumulators compared to soils are more pronounced for more volatile NBFRs. In addition, the concentrations of NBFRs generally decreased with increasing altitude on the south-facing slope, whereas on the north-facing slope some NBFRs exhibited different trends, suggesting concurrent local and long-range transport sources. Normalization based on total organic carbon/lipid concentrations strengthened the correlation with altitude, implying that the altitude gradient of the mountain slope and forest cover could jointly affect the distribution of NBFRs in the TP. Furthermore, principal components analysis (PCA) with multiple linear regression analysis (MLRA) showed that the average contribution of the mountain cold trapping effect (MCTE) accounted for the major (77%) contribution and forest filter effect (FFE) has only a modest contribution to the deposition of NBFRs in soil.
Показать больше [+] Меньше [-]In vivo and in silico evaluations of survival and cardiac developmental toxicity of quinolone antibiotics in zebrafish embryos (Danio rerio) Полный текст
2021
Han, Ying | Ma, Yuanyuan | Yao, Shangchen | Zhang, Jingpu | Hu, Changqin
Quinolones are ranked as the second most commonly used class of antibiotics in China, despite their adverse clinical and environmental effects. However, information on their cardiac developmental toxicity to zebrafish is limited. This study investigates the relationships between different quinolone structures and toxicity in zebrafish embryos using in vivo and in silico methods. All of the experimentally tested quinolones show cardiac developmental toxicity potential and present mortality and teratogenic effects in a dose-dependent manner. Theoretically, the acute toxicity values predicted using quantitative structure−toxicity relationship (QSTR) modeling based on previously reported LC₅₀ values are in good agreement with the in vivo results. Further investigation demonstrates that the hormetic concentration response of some quinolones may be related to methylation on the piperazine ring at the C-7 position. The amino group at the C-5 position, the methylated or ethylated piperazine group at the C-7 position, halogens at the C-8 position and a cyclopropyl ring at N1 position may be responsible for cardiac developmental toxicity. In terms of survival (key ecological endpoint), the naridine ring is more toxic than the quinoline ring. This combined approach can predict the acute and cardiac developmental toxicity of other quinolones and impurities.
Показать больше [+] Меньше [-]A review on pesticides in flower production: A push to reduce human exposure and environmental contamination Полный текст
2021
Pereira, Patrícia C.G. | Parente, Cláudio E.T. | Carvalho, Gabriel O. | Torres, João P.M. | Meire, Rodrigo O. | Dorneles, Paulo R. | Malm, Olaf
In several countries, flower import regulations are restricted to food security, by establishing maximum residue limits (MRL) for pesticides in flower-based food products and biosafety, in order to limit the circulation of vectors, pests and exotic species across borders. In this context, the lack of limits on pesticides in flower-products for ornamental purposes can influence the pesticide overuse in production areas, as well as the transfer of contaminated products between countries. Therefore, the purpose of this review was to discuss possible adverse effects on human and environmental health of pesticides used in floriculture, evaluating regulations on the use of these pesticides in the main importing and flower-producing countries. This review included 92 documents. The use of 201 compounds was identified by interviews and analytical measurements. Among them, 93 are banned by the European Union (EU), although 46.3 % of these compounds have been identified in samples from European countries. Latin American countries have a large number of scientific publications on pesticides in flower production (n = 51), while the EU and China have less studies (n = 24) and the United States and Japan have no studies. Regarding adverse health effects, poorer neurobehavioral development, reproductive disorders, congenital malformations and genotoxicity have been reported for residents of flower production areas and workers throughout the flower production cycle. Studies including water samples show overuse of pesticides, while environmental impacts are related to water and air contamination, soil degradation and adverse effects on the reproduction and development of non-target organisms. This review points out that the absence of MRL for non-edible flowers can be crucial for the trade of contaminated products across borders, including pesticides banned in importing countries. Furthermore, setting limits on flowers could reduce the use of pesticides in producing countries.
Показать больше [+] Меньше [-]Effect of sterilization on cadmium immobilization and bacterial community in alkaline soil remediated by mercapto-palygorskite Полный текст
2021
Wang, Yale | Xu, Yingming | Huang, Qingqing | Liang, Xuefeng | Sun, Yuebing | Qin, Xu | Zhao, Lijie
Cadmium (Cd) pollution in alkaline soil in some areas of northern China has seriously threatened wheat production and human health. However, there are still few effective amendments for alkaline soil, and the mechanism of amendments with a good immobilization effect remains unclear. In this study, soil sterilization experiments were conducted to investigate the effects of soil microorganisms on the immobilization of a novel amendment—mercapto palygorskite (MPAL) in Cd-contaminated alkaline soils. The results showed that the mercapto on the MPAL surface was not affected by autoclaving. Compared with the control, the available Cd concentration in 0.025% MPAL treatments decreased by 18.80-29.23% after 1 d of aging and stabled after 10 d of aging. Importantly, the immobilization of MPAL on Cd in sterilized soil was significantly better than that in natural soil due to the changes in Cd fractions. Compared with MPAL-treated natural soil, exchangeable Cd fraction and carbonate-bound Cd fraction in MPAL-treated sterilized soil decreased by 20.79–27.09% and 20.05–26.45%, while Fe/Mn oxide-bound Cd fraction and organic matter-bound Cd fraction increased by 17.77–22.68% and 18.85–27.32%. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis found that the potential functions of the microbial community in normal and sterilized soil were different significantly. Soil sterilization increased the soil pH and decreased the arylsulfatase activity, but did not change the soil zeta potential and available sulfur. The changes in Cd fractions in MPAL-treated sterilized soil may be related to the reduction in the bacterial community and the changes in function microbial, but not to the soil properties. In addition, MPAL application had little effects on the bacterial community, soil pH value, zeta potential, available sulfur, and arylsulfatase. These results showed that the immobilization of MPAL on Cd in alkaline soil was stable and effective, and was not affected by soil sterilization and soil microorganism reduction.
Показать больше [+] Меньше [-]Significant bioaccumulation and biotransformation of methyl mercury by organisms in rice paddy ecosystems: A potential health risk to humans Полный текст
2021
Du, Hongxia | Guo, Pan | Wang, Tao | Ma, Ming | Wang, Dingyong
Rice has been confirmed as one of the principal intake pathways for methylmercury (MeHg) in human, however, the impact of edible organisms, such as snails, loaches and eels, living in the rice-based ecosystem to the overall MeHg intake has been overlooked. Here, we conducted a cross-sectional ecological study, and the results showed that bioaccumulation of MeHg in these edible organisms was significantly higher than in paddy soils and rice roots (p < 0.001), even though rice roots and grains have significantly higher total Hg (THg) (p < 0.001). The MeHg/THg ratios were consistently and significantly higher in those edible organisms than in rice grains, suggesting a potential elevated MeHg exposure risk through consumption. Based on results of bioaccumulation factors (BAFs) for MeHg, it was clear that MeHg was bioaccumulated and biotransformed from paddy soils to earthworms and then to eels, as well as from paddy soils to snails and then to eels and loaches, potentially indicating that the consumption of eels and loaches was absolutely pernicious to people regularly feeding on them. Overall, MeHg was biomagnified along the food chain of the paddy ecosystem from soil to the organisms, and it was of potential higher risks for local residents to eat them, especially eels and loaches. Therefore, it is intensely indispensable for people fond of such diets to attenuate their consumption of rice, eels and loaches, thus mitigating their MeHg exposure risks.
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