The concentration of persistent organic pollutants (POPs) makes remarkable difference to environmental fate. In the field of passive sampling, the partition coefficients between polystyrene-divinylbenzene resin (XAD) and air (i.e., KXAD₋A) are indispensable to obtain POPs concentration, and the KXAD₋A is generally thought to be governed by temperature and molecular structure of POPs. However, experimental determination of KXAD₋A is unrealistic for countless and novel chemicals. Herein, the Abraham solute descriptors of poly parameter linear free energy relationship (pp-LFER) and temperature were utilized to develop models, namely pp-LFER-T, for predicting KXAD₋A values. Two linear (MLR and LASSO) and four nonlinear (ANN, SVM, kNN and RF) machine learning algorithms were employed to develop models based on a data set of 307 sample points. For the aforementioned six models, R²ₐdⱼ and Q²ₑₓₜ were both beyond 0.90, indicating distinguished goodness-of-fit and robust generalization ability. By comparing the established models, the best model was observed as the RF model with R²ₐdⱼ = 0.991, Q²ₑₓₜ = 0.935, RMSEₜᵣₐ = 0.271 and RMSEₑₓₜ = 0.868. The mechanism interpretation revealed that the temperature, size of molecules and dipole-type interactions were the predominant factors affecting KXAD₋A values. Concurrently, the developed models with the broad applicability domain provide available tools to fill the experimental data gap for untested chemicals. In addition, the developed models were helpful to preliminarily evaluate the environmental ecological risk and understand the adsorption behavior of POPs between XAD membrane and air.

Several recent studies have looked into the differences in air qualities inside popular commute modes. The impact of daily commuting patterns and work-related trips on inhalation doses, however, are not investigated. The purpose of this study is to quantify the variation in air pollutants within popular commute modes in Mumbai, India, and to estimate the variation in exposure as a result of occupational or work-related trips across different sub-groups. Real-time pollutants, both gaseous and particulate matters (PM), were measured on a pre-defined route during rush and non-rush hours on buses, cars, auto-rickshaws, sub-urban trains, and motorbikes through several trips (N = 98). Household surveys were conducted to estimate the exposures of different occupational subgroups (cab-driver, auto-rickshaw drivers, delivery persons) and people commuting to their offices daily. Participants (N = 800) from various socioeconomic backgrounds in the city were asked about their job categories, work-activity patterns, and work-related commute trips. Mass concentrations of particles in different size ranges (PM₁, PM₂.₅, and PM₁₀) were substantially higher (p < 0.05) inside auto-rickshaws (44.6 μg/m³, 84.7 μg/m³, and 138.3 μg/m³) compared to other modes. Inside cars, gaseous pollutants such as carbon monoxide (CO) and total volatile organic compounds (TVOC) were significantly higher (p < 0.05). Although both gaseous and particulate concentrations were lower (p < 0.05) inside buses, bus-commuters were found to be highly exposed to the pollutants due to the extended trip time (∼1.2 times longer than other modes) and driving conditions. Office commuters inhale a large fraction of their daily doses (25–30%) during their work-related travel. Occupational sub-groups, on the other hand, inhale ∼90% of the pollutants during their work. In a day, an auto-rickshaw driver inhales 10–15% more (p < 0.05) pollutants than cab driver or delivery personnel. Therefore, this study highlights the inequalities in occupational exposure as a combined effect of in-cabin air qualities and commute patterns due to occupational obligations.

Marine debris has become a major form of pollution and a serious ecosystem health concern. The present study evaluates the accumulation, origin, and fate of debris in intertidal coral habitats of Mumbai-one of the world's highly populated coastal cities on the west coast of India. Predominantly, seven hermatypic coral species belonging to seven genera and five families were identified and mainly represented by Pseudosidastrea, Porites, and Bernardpora. In terms of number, the mean density of marine debris was 1.60 ± 0.13 SE items/m², which is higher than the global average. The mean density of plastic debris was 1.46 ± 0.14 SE items/m². Approximately 9% of total coral colonies were in physical contact with debris, and 22% of these colonies showed visible signs of partial bleaching. Single use plastic bags and wrappers were dominant plastic debris. The study area was characterized as ‘very poor cleanliness’ according to the Beach Quality Indexes, which include the Clean Coast Index, General Index, and Hazardous Items Index. The numerical model indicates the influence of river discharge and probable areas of plastic accumulation with high tidal currents in this region, maneuvering the spatial advection of litter in the nearshore areas. Combined analysis of ground-truthing and model simulation implies that the possible contributing sources of litter were representatives of land-based and sea-originated. The overall results point to increasing anthropogenic stressors threatening coastal coral communities, including marine debris pollution. It is advocated to adopt an integrated coastal zone management approach supported by coordinated policy frameworks could guide the mitigation of the debris footprint in coastal environments.

Common air pollutants, such as nitrogen oxides (NOₓ), emitted in diesel exhaust, and ozone (O₃), have been implicated in the decline of pollinating insects. Reductionist laboratory assays, focused upon interactions between a narrow range of flowering plant and pollinator species, in combination with atmospheric chemistry models, indicate that such pollutants can chemically alter floral odors, disrupting the cues that foraging insects use to find and pollinate flowers. However, odor environments in nature are highly complex and pollination services are commonly provided by suites of insect species, each exhibiting different sensitivities to different floral odors. Therefore, the potential impacts of pollution-induced foraging disruption on both insect ecology, and the pollination services that insects provide, are currently unknown. We conducted in-situ field studies to investigate whether such pollutants could reduce pollinator foraging and as a result the pollination ecosystem service that those insects provide. Using free-air fumigation, we show that elevating diesel exhaust and O₃, individually and in combination, to levels lower than is considered safe under current air quality standards, significantly reduced counts of locally-occurring wild and managed insect pollinators by 62–70% and their flower visits by 83–90%. These reductions were driven by changes in specific pollinator groups, including bees, flies, moths and butterflies, and coincided with significant reductions (14–31%) in three different metrics of pollination and yield of a self-fertile test plant. Quantifying such effects provides new insights into the impacts of human-induced air pollution on the natural ecosystem services upon which we depend.

Perfluorooctane sulfonic acid (PFOS) is a persistent environmental pollutant. Exposure to PFOS has been associated with abnormal fetal development. The long non-coding RNA (lncRNA) has been showed to play a role in fetal growth restriction (FGR), preeclampsia (PE) and other pregnancy complications. Whether the lncRNA contributes to PFOS-induced toxicity in the placenta remains unknown. In this study, we investigated the function of lncRNA MEG3 and its derived miR-770 in PFOS-induced placental toxicity. Pregnant mice received gavage administration of different concentrations of PFOS (0.5, 2.5, and 12.5 mg/kg/day) from GD0 to GD17, and HTR-8/SVneo cells were treated with PFOS in the concentrations of 0, 10⁻¹, 1, 10 μM. We found that expression levels of miR-770 and its host gene MEG3 were reduced in mice placentas and HTR-8/SVneo cells with exposure of PFOS. A significant hypermethylation was observed at MEG3 promoter in placentas of mice gestational-treated with PFOS. We also confirmed that MEG3 and miR-770 overexpression alleviated the cell growth inhibition induced by PFOS. Furthermore, PTX3 (Pentraxin 3) was identified as the direct target of miR-770 and it was enhanced after PFOS exposure. In summary, our results suggested that MEG3 alleviate PFOS-induced placental cell inhibition through MEG3/miR-770/PTX3 axis.

Thallium, a highly toxic heavy metal and priority pollutant, has been widely reported to cause neurodevelopmental toxicity in animals. However, accessible epidemiological studies concerning the neurodevelopmental toxicity of early-life thallium exposure in humans are limited. In a prospective birth cohort including 2164 mother-child pairs, we explored the effect of prenatal serum thallium exposure on cognitive development among preschool-aged children born in Ma'anshan, Anhui, China. Serum thallium concentrations were measured in the first trimester, second trimester, third trimester, and cord blood by inductively coupled plasma mass spectrometry (ICP-MS). Child cognitive development was appraised by the Chinese version of the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-IV) at 4.5 years old. Multiple informants generalized estimating equations (GEEs) were fit to jointly estimate the association between the four repeated measurements of thallium concentrations and the preschool-aged children's cognitive test scores. After adjusting for potential confounders, the visual spatial index (VSI) was 1.45 points lower in the highest tertile of serum thallium during the first trimester than in the lowest tertile (p for trend = 0.04). Moreover, children in the highest tertile of serum thallium during the third trimester had a significantly lower full-scale intelligence quotient (FSIQ) (β = −1.51, 95% CI: −2.68, −0.35), VSI (β = −1.79, 95% CI: −3.16, −0.42), fluid reasoning index (FRI) (β = −1.41, 95% CI: −2.73, −0.10), and processing speed index (PSI) (β = −1.47, 95% CI: −2.71, −0.24) scores than the children in the lowest tertile. When performing stratified analysis by child sex, the associations of first- and third-trimester thallium concentrations with cognitive test scores were more prominent in boys than in girls. Our findings revealed that maternal serum thallium exposure during the first and third trimesters, but not other periods, had detrimental effects on preschoolers' cognitive development, and these effects showed sex differences.

Exposure of the general population to airborne metals remains poorly estimated despite the potential health risks. Passive moss biomonitoring can proxy air quality at fine resolution over large areas, mainly in rural areas. We adapted the technique to urban areas to develop fine concentration maps for several metals for Constances cohort's participants. We sampled Grimmia pulvinata in 77 and 51 cemeteries within ∼50 km of Paris and Lyon city centers, respectively. We developed land-use regression models for 14 metals including cadmium, lead, and antimony; potential predictors included the amount of urban, agricultural, forest, and water around cemeteries, population density, altitude, and distance to major roads. We used both kriging with external drift and land use regression followed by residual kriging when necessary to derive concentration maps (500 × 500 m) for each metal and region. Both approaches led to similar results. The most frequent predictors were the amount of urban, agricultural, or forest areas. Depending on the metal, the models explained part of the spatial variability, from 6% for vanadium in Lyon to 84% for antimony in Paris, but mostly between 20% and 60%, with better results for metals emitted by human activities. Moss biomonitoring in cemeteries proves efficient for obtaining airborne metal exposures in urban areas for the most common metals.

In recent years, Feammox has made it possible to remove NH₄⁺-N under anaerobic conditions; however, its application in practical wastewater treatment processes has not been extensively reported. In this study, an up-flow anaerobic biological filter based on limonite (Lim-UAF) was developed to facilitate long-term and stable treatment of domestic sewage. Lim-UAF achieved the highest removal efficiency of chemical oxygen demand (COD) and NH₄⁺-N at a hydraulic retention time (HRT) of 24 h (Stage II). Specifically, the COD and NH₄⁺-N content decreased from 240.8 and 30.0 mg/L to about 7.5 and 0.35 mg/L, respectively. To analyze the potential nitrogen removal mechanism, the Lim-UAF was divided into three layers according to the height of the reactor. The results showed that COD and NH₄⁺-N removal had remarkable characteristics in Lim-UAF. More than 55.0% of influent COD was removed in the lower layer (0–30 cm) of Lim-UAF, while 60.2% of NH₄⁺-N was removed in the middle layer (30–60 cm). Microbial community analysis showed that the community structure in the middle and upper layers (60–90 cm) was relatively similar, but quite different from that of the lower layer. Heterotrophic bacteria were dominant in the lower layer, whereas iron-reducing and iron-oxidizing bacteria were enriched in the upper and middle layers. The formation of secondary minerals (siderite and Fe(OH)₃) indicated that the Fe(III)/Fe(II) redox cycle occurred in Lim-UAF, which was triggered by the Feammox and NDFO processes. In summary, limonite was used to develop a single-stage wastewater treatment process for simultaneously removing organic matter and NH₄⁺-N, which has excellent application prospects in domestic sewage treatment.

Due to worldwide production, sales and application, neonicotinoids dominate the global use of insecticides. While, neonicotinoids are considered as pinpoint neurotoxicants that impair cholinergic neurotransmission in pest insects, the sublethal effects on nontarget organisms and other neurotransmitters remain poorly understood. Thus, we investigated long-term neurological outcomes in the decomposer nematode Caenorhabditis elegans. In the adult roundworm the neonicotinoid thiacloprid impaired serotonergic and dopaminergic neuromuscular behaviors, while respective exposures to thiamethoxam showed no effects. Thiacloprid caused a concentration-dependent delay of the transition between swimming and crawling locomotion that is controlled by dopaminergic and serotonergic neurotransmission. Age-resolved analyses revealed that impairment of locomotion occurred in young as well as middle-aged worms. Treatment with exogenous serotonin rescued thiacloprid-induced swimming deficits in young worms, whereas additional exposure with silica nanoparticles enhanced the reduction of swimming behavior. Delay of forward locomotion was partly caused by a new paralysis pattern that identified thiacloprid as an agent promoting a specific rigidity of posterior body wall muscle cells and peripheral neuropathy in the nematode (lowest-observed-effect-level 10 ng/ml). On the molecular level exposure with thiacloprid accelerated protein aggregation in body wall muscle cells of polyglutamine disease reporter worms indicating proteotoxic stress. The results from the soil nematode Caenorhabditis elegans show that assessment of neurotoxicity by neonicotinoids requires acknowledgment and deeper research into dopaminergic and serotonergic neurochemistry of nontarget organisms. Likewise, it has to be considered more that different neonicotinoids may promote diverse neural end points.

Ambient particulate air pollution is a risk factor for cardiovascular and respiratory disease, yet the biological mechanisms underlying this association are not well understood. The current study aimed to investigate the mediation role of microRNAs on the association between personal PM₂.₅ exposure and blood pressure and lung function. One hundred and twenty adults (60 truck drivers and 60 office workers) aged 18–46 years were assessed on the June 15, 2008 and at follow-up (1- to 2-weeks later). MicroRNAs were extracted from the peripheral blood samples. Compared to truck drivers, there is a significant increase in FEF₂₅₋₇₅, FEV₁, and FEV₁/FVC and a decrease in PM₂.₅ in office workers (all p < 0.05). According to the Bonferroni corrected threshold p-value < 6.81 × 10⁻⁵ (0.05/734) used, personal PM₂.₅ data showed a significant positive association with miR-644 after the adjustment for age, BMI, smoking status, and habitual alcohol use. The mediation effect of miR-644 on the association between personal PM₂.₅ exposure and FEF₂₅₋₇₅ [B (95%CI) = −1.342 (−2.810, −0.113)], PEF [B (95%CI) = -1.793 (−3.926, −0.195)], and FEV₁/FVC [B (95%CI) = −0.119‰ (−0.224‰, −0.026‰)] was significant only for truck drivers after the adjustment for covariates. There were no similar associations with blood pressure. These results demonstrate microRNAs to potentially mediate association of PM₂.₅ with lung function. Subsequent studies are needed to further elucidate the potential mechanisms of action by which the mediation effect of microRNAs is achieved with this process.