This is a cross-sectional study with data and biological material collection from vineyard farmers in southern Brazil. An interview was carried out through a questionnaire developed according to the reference guide of the state government. Plasma and urine samples were screened for Aluminum, Chromium, Manganese, Copper, Nickel, Cobalt, Zinc, Arsenic, Selenium, Cadmium, Antimony, Barium, Mercury, Lead and Uranium, with a technique for fast determination of these elemental contents in biological material utilizing dynamic reaction cell inductively coupled mass spectrometry. Principal component analysis was used to identify associations between these elemental contents in biological samples and the information obtained from the interviews. The farmers showed some trace elements in plasma and urine at a higher concentration than unexposed populations from other studies. This study highlights recent findings of trace elements in biological material and their association with characteristics of pesticide use. In addition, it also contributes to the gap in the literature regarding trace elements content in plasma and urine of workers exposed to pesticides.

The anaerobic digestion (AD) of food waste (FW) was augmented with ammonia-tolerant anaerobic sludge (ATAS). Different inoculum substrate ratios (ISR) under an initial ammonia stress of 4220 mg N/L were investigated. Results showed that the average specific methane production (SMP) of FW in the ATAS system increased by 36% compared with that in un-acclimated anaerobic sludge. SMP with ISR of 1:2.5 increased by approximately 6 times. Volatile fatty acids (VFAs) accumulation and sharp pH decline were not detected. These results revealed the high performance of ATAS in simultaneously relieving ammonia and acid stress. This improvement was attributed to multiple factors. ATAS had high ammonia tolerance and ability in conversion of acetate into methane. The equilibrium of NH₃/NH₄⁺, CO₂/H₂CO₃/HCO₃⁻, and CₓHyCOOH/CₓHyCOO⁻ could promote VFAs and ammonia ionization, reduce the levels of free VFAs and ammonia, neutralize pH, and thus enhance the system’s buffering capacity to be less susceptible to fluctuations. These results demonstrated that employing ATAS in improving AD performance and resilience from acid and ammonia inhibition is feasible and effective.

In this study, we elucidated the potential protective effects of graviola leaves, compared with sulfasalazine, against acetic acid (AA)–induced ulcerative colitis (UC) in rats. Twenty-eight mature male rats were divided into four groups, Sham, Colitis, Colitis/Sulfa, and Colitis/Graviola, and were treated orally with either saline, saline, sulfasalazine (100 mg/kg/day), or graviola (100 mg/kg/day), respectively, for 7 days. On the 4th day, UC was induced by transrectal administration of 4% AA. Colon tissues were excised for macroscopic and histopathological evaluation and immunohistochemical analysis of caspase-3, B-cell lymphoma 2 (Bcl-2), and Bcl-2-associated X protein (Bax). Also, levels of oxidative mediators, Wnt family member1 (Wnt1), smoothened (Smo), and glioblastoma-1 (Gli1) were evaluated. Macroscopic and histopathological examination revealed that both graviola and sulfasalazine significantly mitigated colonic damage. Besides, both treatments significantly alleviated AA-induced oxidative stress, as evidenced by reduced nitric oxide (No) and malondialdehyde (MDA) levels and myeloperoxidase (MPO) activity and raised reduced glutathione (GSH) content. Both treatments significantly attenuated AA-induced apoptosis via downregulating the expression of Bax and caspase-3 and upregulating the expression of the anti-apoptotic protein, Bcl-2. Furthermore, downregulation of mRNA expression of Wnt1 with concomitant upregulation of Smo and Gli1 was observed in rats treated with either sulfasalazine or graviola. Based on these observations, graviola may attenuate AA-induced UC, at least partially, by modulating apoptosis and Wingless/Int1 (Wnt) and hedgehog (Hh) signaling crosstalk.

Data from National Health and Nutrition Examination Survey for 2003–2016 for US adults aged ≥ 20 years (N = 10,942) were used to study variabilities and associations with urinary albumin creatinine ratio (UACR) in the adjusted concentrations (AGM) of urine bisphenol A (BPA) across various stages of renal function (RF). RF stages considered were RF-1 (eGFR > 90 mL/min/1.73 m²), RF-2 (60 ≤ eGFR ≤ 90 mL/min/1.73 m²), RF-3A (45 ≤ eGFR < 60 mL/min/1.73 m²), and RF-3B/4 (15 ≤ eGFR < 45 mL/min/1.73 m²). Irrespective of gender, race/ethnicity, and smoking status, AGMs for BPA were located on U-curves with point of inflection at RF-2. In general, decreases from RF-1 to RF-2 were followed by increases from RF-2 to RF-3A and from RF-3A to RF-3B/4. For example, AGMs for males were observed to be 1.52, 1.48, 1.61, and 1.69 ng/mL at RF-1, RF-2, RF-3A, and RF-3B/4 respectively. A similar U-curve was observed for those without albuminuria but for those with albuminuria, BPA levels continued increasing until RF-3A before decreasing at RF-3B/4. Severe kidney dysfunction was found to be associated with statistically significantly higher concentrations of BPA in urine. Shape of concentration curves for BPA across RF stages is determined by the balance of actively mediated secretion and reabsorption operating on both sides of renal proximal tubules during each stage of RF. Shape of concentration curves for BPA across various stages of RF was age and concentration dependent. Associations between BPA and UACR were found to be negative (p = 0.02), positive (p = 0.23), negative (p = 0.53), and negative (p < 0.01) respectively at RF-1, RF-2, RF-3A, and RF-3B/4 respectively.

Palladium (Pd) is widely used in automotive catalytic converters to reduce toxic gas emissions. The input of Pd in the rainfall-runoff is an important contributing factor to the accumulation of Pd in receiving water bodies. In this study, the Meishe River in Haikou, Hainan Province, China, was used as the research area, and palladium (Pd) was selected as the target pollutant. This study explored the response of Pd in the receiving water body to rainfall-runoff and to analyze the influencing factors. The results showed that the dissolved Pd concentration in the receiving water body had a corresponding relationship with that in rainfall-runoff. The response of suspended Pd in the receiving water body to rainfall-runoff was closely related to the location of the drainage outlet. Compared with that of suspended Pd, the response of dissolved Pd in the receiving water body to that in the rainfall-runoff was more obvious. Seven meters downstream from the outfall was the most sensitive response distance of dissolved Pd in receiving water bodies to rainfall-runoff, and the response time was approximately 0–10 min. The suspended Pd at 3 m downstream from the outfall also had a certain response to the rainfall-runoff, and the response time was approximately 15–25 min. The response time of the suspended Pd in the receiving water body depended largely on the first flush ability of the runoff. There was a moderately positive correlation between the dissolved Pd and Cl⁻ in the receiving water body (r = 0.687; p < 0.05). The effects of pH, Eh, and total suspended solids (TSS) on suspended Pd were reduced in the response process of the receiving water body. The synergistic effect of multiple factors increased the uncertainty of the Pd response.

The reforming and opening-up and the development of agricultural science and technology have brought about the rapid growth of China’s food quantity and solved the problem that 20% of the world’s population has enough to eat. At the same time, it also brings the problem of harmful residues in food. On the one hand, the Chinese government guides farmers to rationally use chemical fertilizers, pesticides, and veterinary drugs. On the other hand, in urban and rural school canteens and farmers’ markets in third-tier cities, the implementation of pesticide residue detection system. Through the investigation of 24 kinds of edible agricultural products which are easy to produce harmful residues, and using a variety of statistical methods, the results showed that at present, the residues of harmful substances in edible agricultural products consumed by urban residents and school canteens in urban and rural areas have been well controlled, and the compliance rate is about 80%. The residues of harmful substances in edible agricultural products consumed by rural residents obviously exceed the standard. Taking rice production as an example, although farmers can reduce the risk of excessive pesticide residues in rice through rational application of pesticides, they are more worried about less application of pesticides and bear the risk of reducing rice production. Most farmers still choose to take the risk of excessive pesticide residues.

The interaction and the interplay of climate change with oil palm production in the Southeast Asia region are of serious concern. This particularly applies in Malaysia due to its rank as the second largest palm oil producer in the world. The anthropogenic activities and the agroecological practices in oil palm plantation, including excessive use of fertilisers, bush fire due to land clearing, and cultivation on peatland, have exacerbated the effects of climate change featuring extreme events, drought, flooding, heatwave, as well as infestation of pest and diseases. These adverse impacts on oil palm production highlight the significance of deploying effective adaptation strategies. The study aims to examine the impact of climate change on oil palm production and identify the farmers’ adaptation strategies to the impacts of climate change in Malaysia. This study was conducted a comprehensive review of the articles published from 2000 to 2021 in the contexts of climate change and oil palm production in Malaysia. The review shows that climate change has a range of impacts on the oil palm production in Malaysia. As a result, several adaptation options were identified, such as breeding of hybrid varieties that are tolerant and resistant to heat; sustainable management of soil; pit and tranches to enhance water management in plantation areas; minimal use of fertilisers, herbicides, and pesticides; zero burning; and minimum tillage. The reviewed studies recommended the following to mitigate the adverse impacts of climate change: sustainable national policy on climate change, conservation of the existing carbon stock, effective management of tropical rainforest biodiversity, afforestation for carbon sequestration, and reduction in greenhouse gas (GHG) emission.

Plastic is a ubiquitous material used across the globe. It is easily transported to various habitats and can then be ingested by animals, with the potential to bioaccumulate up the food chain further. Although classified as solid waste, some plastics can be considered hazardous waste due to the chemicals used in the production process and those that can be adsorbed, such as hydrophobic pollutants in seawater. Plastics can break down into secondary particulate plastics, or be microscopically primary plastics, smaller than 5 mm. Marine organisms of all sizes can mistake plastic for food or consume prey with microplastics. This can cause detrimental toxic effects at a cellular, biochemical, and muscular level. This research uses a systematic quantitative literature review (SQLR) method to determine the most common polymers, hazardous chemicals, and marine organisms to ingest microplastic and incur ecotoxicological consequences. The results indicated polyethylene (PE), polypropylene (PP), and polystyrene (PS) to be the topmost common polymers, with sizes between 1 and 100 μm. Plastic was observed to be a sink for non-additive pollutants more than a vector. Persistent organic pollutants (POPs) were the most common pollutants found. Biological impacts and side effects included mortality, reproductive effects, genotoxicity, accumulation, and behavioral effects. Further research is needed regarding the interrelationship of plastic polymers, additives, and non-additives combined for inducing toxic effects.

Stable isotopes (δDVSMOW and δ¹⁸OVSMOW) and hydrochemical characteristics were analyzed to determine the groundwater and surface water characteristics of the Taizi River Basin in Northeast China. Total dissolved solids and major ion concentrations gradually increase along the Taizi River, and only parts of the middle and lower reaches were slightly reduced by replenishment from the Hun River and the tributaries of the eastern mountainous areas. The hydrochemical evolution of the surface water and groundwater may be due to a combination of mineral dissolution, mixing processes, cation exchange, and evaporation along the groundwater flow path. The geochemical and isotopic characteristics of the waters suggest that the surface water from the piedmont recharges the groundwater through faults and that precipitation near the mountain reservoirs contributes immensely to both water types. Lateral groundwater movement from the piedmont may be an effective source for replenishing river water in the middle and lower reaches. The geochemical and isotopic characteristics of the groundwater and surface water interaction in the Taizi River Basin contribute toward their comprehensive management.

COVID-19 pandemic waves hitting worldwide result in drastic postinfection complications with interindividual variations, which raised the question for the cause of these observed variations. This urged to think “the impact of environment-affected genes”? In an attempt to unravel the impact of environment-affected genes, a systematic rapid review was conducted to study “the impact of host or viral epigenetic modulation on COVID-19 infection susceptibility and/or outcome.” Electronic databases including Web of Science, SCOPUS, Cochrane Central Register of Controlled Trials, PubMed, and Google Scholar, and other databases were searched. The search strings included “COVID-19” OR “SARS-CoV-2” AND (Epigenetics’). Articles with randomized clinical trials (RCTs) and observational study designs, conducted on humans and available in the English language, were selected, with respect to “The interplay between the SARS-CoV-2 virus and Epigenetics” published from 2020 to February 2021 (but not limited to 2020, being expanded to 2015). Database search yielded 1330 articles; after screening, exclusion, and further filtrations, 51 articles were included. Susceptibility to COVID-19 infection is related to the viral-microRNAs (miRNAs) which alter virulence of the transmitted SARS-CoV-2 strains and impact host-miRNA-related innate immunity. Host-DNA methylation and/or chromatin remodeling may be implicated in severe cytokine storm that can ultimately results in fatal outcome.