Nine multiparous cows were biopsied twice – in the first and fifth week after parturition in winter 2004/2005 on the Research and Study farm Vecauce of Latvia University of Agriculture. The aim of the research was to reveal distribution of inflammatory factors and apoptosis in the cow’s endometrium in post parturition period. Haematoxylin and eosin were used for routine staining of each sample. Tumor necrosis factor α (TNFα, w.d. 1:100, Abcam, England), and interleukin 10 (IL10, w.d. 1:400, Abcam, England) were detected immunohistochemically (IMH), and TUNEL method was used for detection of apoptosis. Distribution of these factors and substances was determined semiquantitatively by counting positive structures in visual fields. A significant increase in the total amount of inflammatory cells, as well as in the amount of the TNFα and apoptotic cells in endometrium between the first and fifth week after parturition (p is less than 0.01) was observed. A significant positive correlation (r=0.41; p is less than 0.01) between infiltration of endometrium with neutrophils and with macrophages was detected in the first week after parturition. A mild positive correlation (r=0.52; p is less than 0.01) between neutrophils and lymphocytes, as well as between lymphocytes and macrophages (r=0.35; p is less than 0.01) was found four weeks after parturition. A mild positive correlation (p is less than 0.05) was observed between amount of inflammatory cells and TNFα (r=0.52), and number of apoptotic cells and TNFα (r=0.58). The research suggests that inflammatory factors and apoptosis intensively act during the process of involution in the cows’ endometrium from the first up to the fifth week after parturition. Intensity, amount and activity of these components show individual variations in each case.