In recent years, there have been unexplained colony losses around the world. Due to the decrease in honey bee colonies, many studies have been carried out to investigate potential causes. One of the main causes of losses is also insecticides. Insecticides used against harmful insects in agricultural fields affect not only harmful ones but also beneficial insects such as honey bees directly or indirectly. Honey bee losses are more common, especially where insecticides are used, and the immune systems of bees exposed to insecticides in these areas weaken; foraging behavior, the ability to smell and learn is impaired. In addition, it leaves residues in bee products such as honey, wax, pollen and bee bread. Effective and sustainable solutions are sought worldwide in order to cope with these losses that pose a major ecological threat. This review aims to reveal the current situation by examining the effects of insecticides on honey bee behavior and physiology.