Green roofs are strategic tools that can play a significant role in the creation of sustainable and resilient cities. They have been largely investigated thanks to their high retention capacity, which can be a valid support to mitigate the pluvial flood risk and to increase the building thermal insulation, ensuring energy saving. Moreover, green roofs contribute to restoring vegetation in the urban environment, increasing the biodiversity and adding aesthetic value to the city. The new generation of multilayer green roofs present an additional layer with respect to traditional ones, which allows rainwater to be stored, which, if properly treated, can be reused for different purposes. This paper offers a review of benefits and limitations of green roofs, with a focus on multilayer ones, within a Water-Energy-Food-Ecosystem nexus context. This approach enables the potential impact of green roofs on the different sectors to be highlighted, investigating also the interactions and interconnections among the fields. Moreover, the Water-Energy-Food-Ecosystem nexus approach highlights how the installation of traditional and multilayer green roofs in urban areas contributes to the Development Goals defined by the 2030 Sustainable Agenda.