There is increasing interest in the development of Coenzyme Q10 (CoQ10) ingredients appropriate for functional food formulations, due to its potential health effects. The present work reported that food proteins including milk and soy proteins can effectively perform as vehicles to remarkably improve water dispersibility, stability and even bioaccessibility of CoQ10. The improvement was mainly due to the formation of protein-CoQ10 complexes, through hydrophobic interactions. The formation of complexes with CoQ10 distinctly changed the physicochemical properties of food protein particles that seemed to be more favorable for their colloidal stability. The complexation remarkably improved the stability against UV exposure or in vitro digestion, and bioaccessibility of CoQ10. In contrast, milk proteins (sodium caseinate and whey protein concentrate) were more appropriate to perform as vehicles for improved bioaccessibility of CoQ10 than soy protein isolate. The findings provide an effective strategy to improve the delivery and bioaccessibility of CoQ10 for the formulation of functional foods enriched with CoQ10.

International audience | Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and antibiofilm activities of the synthetized complex were assessed against Escherichia coli , Staphylococcus aureus , Listeria monocytogenes , and Enterococcus faecalis. The results revealed that the ruthenium (II) complex has higher antibacterial and antibiofilm activities in comparison with free ligands or the enantiopure (R)-limonene. Moreover, microencapsulation of this complex reduced its cytotoxicity and improved their minimum inhibitory concentration and antibiofilm activity toward the considered bacteria. The ruthenium (II) complex targets the bacterial cell membrane, which leads to rapid leakage of intracellular potassium. Our study suggests that the developed ruthenium (II) complexes could be useful as an alternative to conventional disinfectants.

Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and antibiofilm activities of the synthetized complex were assessed against Escherichia coli, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis. The results revealed that the ruthenium (II) complex has higher antibacterial and antibiofilm activities in comparison with free ligands or the enantiopure (R)-limonene. Moreover, microencapsulation of this complex reduced its cytotoxicity and improved their minimum inhibitory concentration and antibiofilm activity toward the considered bacteria. The ruthenium (II) complex targets the bacterial cell membrane, which leads to rapid leakage of intracellular potassium. Our study suggests that the developed ruthenium (II) complexes could be useful as an alternative to conventional disinfectants.