In this paper, we shall resume some of our research in the field of water security and sustainable economic development. Therefore, we define and further analyze the concept of water security, highlighting its actual increased importance for sustained economic growth and poverty alleviation. While the global demand for food is rising, there are several actors that will critically limit food production: the increased urbanization, the rising prices on inputs, the pressure on water resources and the increased crops and livestock vulnerability to climate change.We may find a strong link between water security and food security, in the global resource nexus model. These issues are shown to be important also in Romania, in our times of climate change and of increased small-scale farmers’ vulnerability. In agreement with the experts and considering the strategic relevance of these aspects, we aim to stress more on the importance of investment in water infrastructure in the rural areas of Romania, to achieve the water security required for a sustainable agri-food and rural development. Moreover, we highlight directions of integrated water management in view of a green economy. As a main recommendation is the need to implement programs and policies promoting water security, as well as water resource efficiency in the Romanian agriculture and rural development programs.

<i>Giardia duodenalis</i> and <i>Cryptosporidium</i> spp. are important zoonotic protozoan pathogens that infect the gastro-intestinal tract of numerous vertebrates, including humans, and both parasites are responsible for water- or food-borne outbreaks of disease worldwide. Although, globally, both parasites are highly prevalent, particularly in developing countries, epidemiological data from Romania are scarce, and genotyping has rarely been performed. The aims of the present study were to investigate the occurrence and genetic diversity of <i>G. duodenalis</i> and <i>Cryptosporidium</i> spp. in patients hospitalized in Northwestern Romania in relation to clinical and paraclinical presentation and to identify the relative frequency of non-specific symptoms and potential risk factors. Between June 2022 and January 2024, 426 fecal samples were screened for gastro-intestinal parasites by rapid tests and microscopical examination, further confirmed by PCR and sequencing. <i>Giardia duodenalis</i> was detected and characterized in 12 samples (2.82%), while <i>Cryptosporidium parvum</i> was confirmed in four samples (0.94%). A majority of positive patients were symptomatic and reported nausea and vomiting with a significantly higher frequency compared to negative ones. This study provides new insights into the epidemiological status and clinical implications of gastro-intestinal parasite species and genospecies in Romania that are necessary for an in-depth understanding of the potential zoonotic transmission and improvement of patient care.