Antimutagenicity potential of Cucurbita maxima flowers
1995
Villasenor, I.M. | Lemon, P. | Palileo, A. (Philippines Univ. Diliman, Diliman, Quezon City (Philippines). Inst. of Chemistry)
The antimutagenicity potential of extracts from Cucurbita maxima, commonly known as squash, flowers was monitored using the Micronucleus Test, an in vivo method using albino mice as test animals. A bioassay directed fractionation and purification scheme using sequential and repeated liquid chromatographic techniques gave a white, crystalline solid, FwB crystals. Results of the Micronucleus Test showed that FwB crystals reduced the number of micronucleated polychromatic erythrocytes induced by tetracycline, a known mutagen, by 59.4 percent. Spectral analysis showed that the FwB crystal is an intractable mixture of closely related sterols
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