The expression of the alfa2 - macroglobulin gene in fetal rat liver during acute phase response
1998
Bogojevic, D. | Stankovic, M. | Petrovic, M. (Institute for Biological Research "Sinisa Stankovic", Belgrade (Yugoslavia). Department of Molecular Biology and Biochemistry)
The expression of the rat alfa2-macroglobulin (alfa2MG) gene was investigated on the model of fetal liver of dams exposed to inflammation on day 19 of pregnancy. The elevation of the alfa2-macroglobulin gene transcriptional activity was found to be acute phase-dependent. Transcriptional regulation and the binding interactions of soluble fetal nucleoproteins and the response element (RE) of alfa2-macroglobulin gene relied on the induction of several preexisting, as well as de novo trans-acting proteins. Preexisting fetal nucleoprotein of 53 kD was identified as a protein of the same molecular mass and epitopes as transcription factor p53.
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