Detoxification and Selectivity of Herbicides by Plant Cytochrome P450
2000
Pyon J.Y. Chungnam National University, Taejon (Korea Republic)
Herbicide selectivity is often based on detoxification which is catalyzed by cytochrome P450 monooxygenases, glutathione S-transferase, glucosyltransferase and other enzymes. Cytochrome P450 plays a significant role in detoxification of herbicides. Cytochrome P450 mediates many metabolic reactions including hydroxylation, dealkylation, deamination, desulfuration, dehalogenation, epoxidation, peroxydation as well as reduction. Enhanced herbicide detoxification is a major mechanism contributing to weed resistance to certain herbicides. Genetic transformation of plants with genes capable of herbicide detoxification has been a successful method to develop herbicide-resistant crops.
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