Effect of Eicosapentaenoic Acid on biochemical parameters in diabetic rat
2003
Christopher, C.L. | Mathuram, L.N. | Sriram, P. (Madras Veterinary College, Chennai (India). Department of Veterinary Pharmacology and Toxiocology)
Effect of eicosapentaexoic acid (EPA) and gliberaclamide (GLC) on streptozotocin induced diabetes in rats was studied. There was a significant reduction (P0.01) in plasma glucose, cholesterol and triglycerides in EPA, GIC and EPA + GLC treated groups over diabetic control group levels. However treatment for 4 weeks did not bring back the value to normal level. Between treatments combination was not found to be a superior over individual treatment. Although the results obtained in the present study reveals a comparable effect between EPA and GLC, further clinical trials are required for firm recommendation.
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