Bioassay-guided isolation of the antimicrobial compounds of Coleus amboinicus Loureiro (Lamiaceae)

Vasquez.E. A.; Kraus, W.; Conrad, J.; Volger, B.; Zebitz, C.; Rejesus, B. M.

Bioassay-guided isolation of the antimicrobial compounds of Coleus amboinicus Loureiro (Lamiaceae)

2004

The essential oil of the aerial part of Coleus amboinicus showed antibacterial activity against Bacillus subtilis (gram +) and Pseudomonas fluorescens (gram -) and antifungal activity against Cladosporium cucumerinum. Bioassay-guided fractionation revealed that carvacrol and p-caryophyllene-4,5-oxide were the major contributors to the antimicrobial activity of the essential oil. The sesquiterpene ct-humulene and monoterpenes oc-pinene, a-terpinene and cymene present in significant amounts were inactive.

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