Bioassay-guided isolation of the antimicrobial compounds of Coleus amboinicus Loureiro (Lamiaceae)
2004
Vasquez.E. A. | Kraus, W. | Conrad, J. | Volger, B. | Zebitz, C. | Rejesus, B. M.
The essential oil of the aerial part of Coleus amboinicus showed antibacterial activity against Bacillus subtilis (gram +) and Pseudomonas fluorescens (gram -) and antifungal activity against Cladosporium cucumerinum. Bioassay-guided fractionation revealed that carvacrol and p-caryophyllene-4,5-oxide were the major contributors to the antimicrobial activity of the essential oil. The sesquiterpene ct-humulene and monoterpenes oc-pinene, a-terpinene and cymene present in significant amounts were inactive.
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