Regulatory effect of retinoic acid on the IGF-I system is related to IRS-1 via PKC-δ and ubiquitin-proteasome pathway in MCF-7 cells
2008
Oh, Y.I. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, J.H. (Chonbuk National University, Jeonju, Republic of Korea) | Kim, S.H. (Chonbuk National University, Jeonju, Republic of Korea) | Kang, C.W. (Chonbuk National University, Jeonju, Republic of Korea), E-mail: [email protected]
These results indicate that the RA-induced activation of PKC-δ effects on the down-regulation of IRS-1 via ubiquitin-proteasome pathway, which is related IGF-I system result in the cell viability. The underlying mechanism could be regulated by the ubiquitin-proteasome pathway through PKC-δ activation. The present findings further indicate that the regulation of RA-induced IGF-I system might be a novel preventive strategy against breast cancer.
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